AI Article Synopsis
- The study aimed to analyze T cell responses to specific hepatitis B virus proteins among four patient groups: acute hepatitis B (AHB), active chronic hepatitis B (CHB), inactive HBV carriers (AsC), and those with past infections.
- Results showed no significant differences in T cell frequencies for HBsAg, HBcAg, and HBeAg between AHB and CHB. However, frequencies were lower in AsC and past infection groups compared to AHB and CHB.
- The study concluded that AsC had the highest T cell response to HBeAg, while other groups showed the strongest responses to HBcAg, suggesting varying immune responses depending on the phase of HBV infection.
Article Abstract
Objective: To analyze the characteristic of T cell response to specific antigen proteins in patients with hepatitis B virus infection.
Methods: 76 cases were recruited, including four groups, acute hepatitis B (AHB), active phase of chronic hepatitis B (CHB), inactive HBV carriers (AsC) and past HBV infection. T cell responses stimulated by 3 antigen specific proteins of HBV were detected using enzyme linked immunospot (ELISPOT) assay.
Results: (1) There were no significant difference in frequencies to HBsAg, HBcAg and HBeAg in AHB and CHB. The frequencies to HBsAg and HBcAg in AsC were lower than that to HBeAg, and the frequencies to HBsAg in group of past HBV infection were significantly lower than that to HBcAg and HBeAg. (2) The frequencies to HBsAg in AHB and CHB both were higher than in group of past HBV infection. The frequencies to HBcAg of AHB, CHB and AsC were higher than that of group of past HBV infection. (3) There were no significant difference in magnitude to HBsAg, HBcAg and HBeAg in AHB and AsC. In CHB, the magnitude to HBsAg was lower than that to HBcAg. The magnitude of in group of past HBV infection were HBcAg > HBeAg > HBsAg. (4) In four groups, the sequence of the magnitude to HBsAg from high to low was AHB, CHB, group of past HBV infection and AsC. The magnitude to HBcAg in of AsC was lower than other three groups. As to the magnitude to HBeAg, the difference was no significant between any two groups except between AHB and CHB.
Conclusions: The T cell responses in group of AsC to HBeAg were the highest, while the T cell responses to HBcAg were the highest in group of other groups.
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