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Elafibranor, a dual PPARα and PPARδ agonist, reduces alcohol-associated liver disease: Lessons from a mouse model.
World J Gastroenterol
January 2025
Carmen Laboratory, INSERM Unit 1060-Lyon 1 University, Pierre Benite 69310, France.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a highly prevalent liver pathology in need of novel pharmacological treatments to complement lifestyle-based interventions. Nuclear receptor agonists have been under scrutiny as potential pharmacological targets and as of today, resmetirom, a thyroid hormone receptor b agonist, is the only approved agent. The dual PPAR α and δ agonist elafibranor has also undergone extensive clinical testing, which reached the phase III clinical trial but failed to demonstrate a beneficial effect on MASLD.
View Article and Find Full Text PDFToward cognitive models of misophonia.
Hear Res
January 2025
Department of Psychology, Concordia University, Montreal, QC, Canada; International Laboratory for Brain, Music and Sound Research (BRAMS), Montreal, QC, Canada; Centre for Research on Brain, Language and Music (CRBLM), Montreal, QC, Canada. Electronic address:
Misophonia is a disorder in which specific common sounds such as another person breathing or chewing, or the ticking of a clock, cause an atypical negative emotional response. Affected individuals may experience anger, irritability, annoyance, disgust, and anxiety, as well as physiological autonomic responses, and may find everyday environments and contexts to be unbearable in which their 'misophonic stimuli' (often called 'trigger sounds') are present. Misophonia is gradually being recognized as a genuine problem that causes significant distress and has negative consequences for individuals and their families.
View Article and Find Full Text PDFA dual-stream model based on PRNU and quaternion RGB for detecting fake faces.
PLoS One
January 2025
Nanjing University of Information Science and Technology, Nanjing, China.
The forensic examination of AIGC(Artificial Intelligence Generated Content) faces poses a contemporary challenge within the realm of color image forensics. A myriad of artificially generated faces by AIGC encompasses both global and local manipulations. While there has been noteworthy progress in the forensic scrutiny of fake faces, current research primarily focuses on the isolated detection of globally and locally manipulated fake faces, thus lacking a universally effective detection methodology.
View Article and Find Full Text PDFDeveloping a Versatile Arsenal: Novel Antimicrobials as Offensive Tools Against Pathogenic Bacteria.
Microorganisms
January 2025
Hainan Province Key Laboratory of One Health, School of Life and Health Sciences, Collaborative Innovation Center of One Health, Hainan University, Haikou 570228, China.
The pervasive and often indiscriminate use of antibiotics has accelerated the emergence of drug-resistant bacterial strains, thus presenting an acute threat to global public health. Despite a growing acknowledgment of the severity of this crisis, the current suite of strategies to mitigate antimicrobial resistance remains markedly inadequate. This paper asserts the paramount need for the swift development of groundbreaking antimicrobial strategies and provides a comprehensive review of an array of innovative techniques currently under scrutiny.
View Article and Find Full Text PDFKnowledge-point classification using simple LSTM-based and siamese-based networks for virtual patient simulation.
BMC Med Inform Decis Mak
January 2025
Department of Computer Science and Information Engineering, National Yunlin University of Science and Technology, Yunlin, Taiwan.
Background: In medical education, enhancing thinking skills is vital. The Virtual Diagnosis and Treatment Platform (VP) refines medical students' diagnostic abilities through interactive patient interviews (simulated patient interactions). By analyzing the questions asked during these interviews, the VP evaluates students' aptitude in medical history inquiries, offering insights into their thinking capabilities.
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