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Objective: To assess the presence of pulmonary embolism and inflammation after polidocanol foam injection into the peripheral veins of rabbits.
Method: The animals were treated with polidocanol foam (1 or 3 mg/kg) or vehicle. Early (15 minutes) and late (30 days) animals were evaluated by perfusional lung scintigraphy and histopathological examination.
Results: In the control group no alterations were found. After polidocanol foam injection it was observed that an important reduction of pulmonary perfusion in the early periods, was mainly in the left lung (P < 0.001), with consequent embolism in the histological evaluation. In late periods it was observed that the presence of thrombus was with fibrin in small veins, compatible with chronic thrombus and the presence of chronic pulmonary inflammation.
Conclusions: The injection of polidocanol foam in experimental animals can induce venous embolism and chronic inflammatory infiltration.
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| http://dx.doi.org/10.1258/phleb.2012.012120 | DOI Listing |
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- Spontaneous hemorrhage from varicose veins can be a dangerous complication, and a two-step clinical protocol was developed to prevent immediate bleeding and ensure long-term results.* -
- The protocol involved a prospective registry of patients, where they received ultrasound assessments and immediate treatment through foam sclerotherapy, followed by planned endovenous ablation within eight weeks.* -
- Out of 59 patients treated, 95% had identifiable underlying issues, and while 52 received the immediate sclerotherapy, only 7 did not; results indicated no recurrent bleeding post-treatment, with a 7% rate of late hemorrhage in long-term follow-up.*
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