AI Article Synopsis
- The study evaluates how MRI can predict the response of advanced rectal carcinoma to neoadjuvant chemoradiation by analyzing tumor characteristics.
- It finds that nonmucinous tumors respond better to treatment than mucinous tumors, which have a poorer prognosis.
- Key MRI parameters, particularly the contrast medium exchange rate, correlate with treatment response, suggesting that these characteristics can help tailor therapeutic approaches.
Article Abstract
Purpose: To assess pretreatment functional and morphological tumor characteristics with magnetic resonance imaging (MRI) in advanced rectal carcinoma and to identify factors predicting response to neoadjuvant chemoradiation.
Materials And Methods: In a prospective study, 95 patients with rectal carcinoma underwent dynamic contrast-enhanced MRI before and after chemoradiation. Quantitative parameters were derived from a pharmacokinetic two-compartment model. Tumors were also characterized with regard to mucinous status at pretreatment high-resolution MRI as nonmucinous or mucinous. Response to treatment was defined as a downshift in the local tumor stage.
Results: The parameter k21 (contrast medium exchange rate) was higher at pretreatment MRI in nonmucinous compared with mucinous carcinomas (P < 0.001). The effect of chemoradiation on dynamic MR parameters was higher in nonmucinous carcinomas than in the mucinous subtype (P < 0.001). A higher rate of response to treatment was linked with nonmucinous morphology (P < 0.001). Multivariate analysis revealed an association between mucinous tumor morphology and poor response (odds ratio [95% confidence interval]: 0.113 [0.032-0.395], P < 0.001) as well as an association between a high 75th percentile of k21 and a higher response rate (odds ratio: 1.043 [1.001-1.086], P = 0.019).
Conclusion: Functional and morphological parameters of pretreatment MRI can assess tumor characteristics associated with the effectiveness of chemoradiation before treatment initiation.
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| http://dx.doi.org/10.1002/jmri.23952 | DOI Listing |
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