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Enhanced porphyrin-based hypoxia imaging by temporal oversampling of delayed fluorescence signal.
J Biomed Opt
February 2025
University of Wisconsin-Madison, Department of Medical Physics, Madison, Wisconsin, United States.
Significance: Protoporphyrin IX (PpIX) delayed fluorescence (DF) is inversely related to the oxygen present in tissues and has potential as a novel biomarker for surgical guidance and real-time tissue metabolism assessment. Despite the unique promise of this technique, its successful clinical translation is limited by the low intensity emitted.
Aim: We developed a systematic study of ways to increase the PpIX DF signal through acquisition sampling changes, allowing optimized imaging at video rates.
Determination of Trends Underlying Aspartic Acid Isomerization in Intact Proteins Reveals Unusually Rapid Isomerization of Tau.
ACS Chem Neurosci
January 2025
Department of Chemistry, University of California, Riverside, California 92521, United States.
Spontaneous chemical modifications in long-lived proteins can potentially change protein structure in ways that impact proteostasis and cellular health. For example, isomerization of aspartic acid interferes with protein turnover and is anticorrelated with cognitive acuity in Alzheimer's disease. However, few isomerization rates have been determined for Asp residues in intact proteins.
View Article and Find Full Text PDFWith a little help from my friends: importance of protist-protist interactions in structuring marine protistan communities in the San Pedro Channel.
mSystems
January 2025
Department of Biological Sciences, University of Southern California, Los Angeles, California, USA.
Unlabelled: Marine protists form complex communities that are shaped by environmental and biological ecosystem properties, as well as ecological interactions between organisms. While all of these factors play a role in shaping protistan communities, the specific ways in which these properties and interactions influence protistan communities remain poorly understood. Fourteen years and 9 months of eukaryotic amplicon (18S-V4 rRNA gene) data collected monthly at the San Pedro Ocean Time-series (SPOT) station were used to evaluate the impacts that environmental and biological factors, and protist-protist interactions had on protistan community composition.
View Article and Find Full Text PDFFood Acquisition Coping Strategies Vary Based on Food Security Among University Students.
Curr Dev Nutr
January 2025
The Family, Interiors, Nutrition & Apparel (FINA) Department, San Francisco State University, San Francisco, CA, United States.
Background: Food insecurity on college campuses is a pressing issue, yet the ways in which students manage challenges and disruptions to their food security status (FSS) are poorly understood.
Objectives: The objective of this study was to examine knowledge of food insecurity as a concept, evaluate FSS, identify food acquisition-related behaviors, and determine whether these behaviors differ among FSS.
Methods: University students at increased risk of experiencing food insecurity ( = 43) were recruited for this mixed-methods study.
Recombinant VSVs: A Promising Tool for Virotherapy.
Acta Naturae
January 2024
Sirius University of Science and Technology, Krasnodar Region, Sirius Federal Territory, 354340 Russian Federation.
Cancer is one of the leading causes of death worldwide. Traditional cancer treatments include surgery, radiotherapy, and chemotherapy, as well as combinations of these treatments. Despite significant advances in these fields, the search for innovative ways to treat malignant tumors, including the application of oncolytic viruses, remains relevant.
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