From plate tectonics theory to psychoneuroimmunology, to medical uses of marijuana, and controlled drinking by alcoholics, there has been a consistent failure by scientists and medical researchers to consider radically new ideas and theories. A review and analysis of these cases and other examples identified numerous reasons or barriers for this failure. Learning from these episodes of failure requires attention to and reflection on these barriers, an understanding of how the scientific process progresses and scientific knowledge evolves, and a willingness to test and evaluate these new ideas and theories before passing final judgment on them.
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http://dx.doi.org/10.3109/10826084.2012.705709 | DOI Listing |
Acc Chem Res
January 2025
Mineralogical Society of Antwerp, Boterlaarbaan 225, 2100 Deurne, Belgium.
ConspectusWhile photochromic natural sodalites, an aluminosilicate mineral, were originally considered as curiosities, articles published in the past ten years have radically changed this perspective. It has been proven that their artificial synthesis was easy and allowed compositional tuning. Combined with simulations, it has been shown that a wide range of photochromic properties were achievable for synthetic sodalites (color, activation energy, reversibility, etc.
View Article and Find Full Text PDFMiddle East J Dig Dis
October 2024
Department of Colorectal Surgery, Colorectal Research Center, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
Background: Low anterior resection (LAR) is the gold standard for curative cancer treatment in the middle and upper rectum. In radically operated patients, the local recurrence rates with total mesorectal excision (TME) after 5 and 10 years was<10%, with 80% in 5 years survival. Anastomotic leakage (AL) affects 4%-20% of patients who underwent LAR.
View Article and Find Full Text PDFJ Appl Clin Med Phys
January 2025
Medical Physics Section, OHS Department, Hamad Medical Corporation, Doha, Qatar.
Purpose: To evaluate image quality (IQ) of for-processing (raw) and for-presentation (clinical) radiography images, under different exposure conditions and digital image post-processing algorithms, using a phantom that enables multiple detection tasks.
Methods: A modified version of the radiography phantom described in the IAEA Human Health Series No. 39 publication was constructed, incorporating six additional Aluminum (Al) targets of thicknesses both smaller and larger than the standard one.
Cancers (Basel)
December 2024
Breast and Gyncological Medical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.
The treatment of hormone receptor positive (HR+), HER-2 negative metastatic breast cancer (MBC) has radically changed over the last few years. CDK4/6 inhibitors combined with endocrine therapy have become the standard of care as a front-line therapeutic approach, conferring a significant improvement in progression-free survival and overall survival compared to traditional endocrine therapy (ET) alone. However, the wide administration of these drugs in clinical practice paved the way for the emergence of new intrinsic and acquired mechanisms of resistance that seem to compromise second-line treatment effectiveness.
View Article and Find Full Text PDFCancers (Basel)
November 2024
Department of Otorhinolaryngology and Head and Neck Surgery-Academic Alliance Skull Base Pathology Radboudumc & MUMC+, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Background: There is no consensus regarding the indication for postoperative radiotherapy (PORT) for T1- and T2-classified squamous cell carcinoma (SCC) of the external auditory canal (EAC) even with negative surgical margins. This study aimed to evaluate whether PORT provides additional benefits for these cases.
Methods: We collected retrospective data from fourteen international hospitals, including resected pT1- and pT2-classified EAC SCC with negative surgical margins.
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