AI Article Synopsis

  • * Key factors influencing plaque vulnerability include inflammation, thrombosis, white blood cell activity, and platelet aggregation, with mechanisms like PS/PSGL-1 linking these processes.
  • * The research explores the potential of Simiao Yongan Decoction to stabilize vulnerable plaques by targeting cell adhesion, inflammation, and thrombosis.

Article Abstract

The vulnerable plaque is the basis for atherosclerosis (AS) plaque rupture and thrombosis, thus further leading to the occurrence of acute cardiovascular events (ACEs). By analyzing the current research situation of atherosclerotic vulnerable plaque, identifying that inflammation and thrombosis are key links in plaque vulnerability, and the roles of white blood cell and platelet aggregation, endothelial cell adhesion and their common connection mechanisms: PS/PSGL-1 in inflammation and the formation of thrombosis. From the viewpoints of inhibiting cell adhesion, fighting against inflammation reaction and thrombosis, the research ideas of Simiao Yongan Decoction in stabilizing atherosclerotic vulnerable plaque were explored.

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