AI Article Synopsis
- CyanoPhyChe is a user-friendly database for exploring cyanobacterial proteins, providing detailed info on their physico-chemical properties, structures, and biochemical pathways.
- The database contains protein sequences from the cyanobacterial genome, enabling calculations of properties like molecular weight, charge, isoelectric point, and hydropathy, which aids in understanding protein behavior and stability.
- Researchers can easily search and export data for proteome analysis, and the database links to other biological resources for further exploration of molecular structures and pathways.
Article Abstract
CyanoPhyChe is a user friendly database that one can browse through for physico-chemical properties, structure and biochemical pathway information of cyanobacterial proteins. We downloaded all the protein sequences from the cyanobacterial genome database for calculating the physico-chemical properties, such as molecular weight, net charge of protein, isoelectric point, molar extinction coefficient, canonical variable for solubility, grand average hydropathy, aliphatic index, and number of charged residues. Based on the physico-chemical properties, we provide the polarity, structural stability and probability of a protein entering in to an inclusion body (PEPIB). We used the data generated on physico-chemical properties, structure and biochemical pathway information of all cyanobacterial proteins to construct CyanoPhyChe. The data can be used for optimizing methods of expression and characterization of cyanobacterial proteins. Moreover, the 'Search' and data export options provided will be useful for proteome analysis. Secondary structure was predicted for all the cyanobacterial proteins using PSIPRED tool and the data generated is made accessible to researchers working on cyanobacteria. In addition, external links are provided to biological databases such as PDB and KEGG for molecular structure and biochemical pathway information, respectively. External links are also provided to different cyanobacterial databases. CyanoPhyChe can be accessed from the following URL: http://bif.uohyd.ac.in/cpc.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504015 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0049425 | PLOS |
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