Mesoporous silica nanoparticle-supported lipid bilayers, or "protocells", exhibit a high loading capacity, enhanced colloidal stability, and peptide-directed, cell-specific uptake, making them especially well-suited for targeted delivery of protein toxins to cancer. Protocells loaded with ricin toxin A-chain (RTA) and targeted to hepatocellular carcinoma cause complete cell death at 30 pM of RTA without affecting the viability of control hepatocytes.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119887 | PMC |
| http://dx.doi.org/10.1002/adhm.201200022 | DOI Listing |
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