Research on vitamins has advanced considerably over the past 100 years with numerous advancements in the fields of biochemistry, medicine, and nutrition. The purpose of this article is to present the history of vitamins using Nobel Prizes as a framework for each vitamin-related discovery. The Nobel Prize Presentation Speech and Nobel Lecture were reviewed for each Nobel Laureate who received an award for vitamin-related research. The original scientific work of a number of awardees was also utilized as a primary source of the history. Nobel Prizes were awarded primarily for the identification, isolation, and synthesis of vitamins. Additional awards recognized the role of specific vitamins in disease processes. The awarding of over 10 Nobel Prizes in Chemistry, Physiology or Medicine in the last century has recognized the seminal work of numerous scientists and physicians and showcased multiple important advancements in vitamins research.
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http://dx.doi.org/10.1159/000343122 | DOI Listing |
Rev Med Liege
January 2025
Service d'Endocrinologie, CHU Liège, Belgique.
In 1849, Thomas Addison discovered alterations in the adrenal glands at autopsy of three patients who had died with idiopathic anemia. Struck by Addison's work, Charles-Edouard Brown-Séquard demonstrated in 1851 that bilateral adrenalectomy in dogs was fatal. It was not until 1950 that the discovery of the hormones of the adrenal cortex, their structure and their biological effects allowed Kendall, Reichstein and Hench to win the Nobel Prize in Physiology or Medicine.
View Article and Find Full Text PDFJ Occup Environ Hyg
January 2025
Finance Department, University of Texas at Austin, Austin, Texas.
The present paper provides an assessment of how the scientific and national policy achievements/goals of Hermann J. Muller were impacted by his ethics and provides several documented episodes in which Muller acted unethically to promote his personal gain-at the expense of others-within the scientific community. Muller manipulated the scientific community in self-serving ways to suppress perspectives that challenged his own views on radiation-induced gene mutation, and hereditary and cancer risk assessment in ways that influenced his significant awards (e.
View Article and Find Full Text PDFCardiol Rev
January 2025
From the Department of Cardiology, Phelps Memorial Hospital/Northwell Health, Sleepy Hollow, NY.
The invention of the string galvanometer by Willem Einthoven in 1901 ushered in a new era of clinical investigation. Previous instruments were capable only of rudimentary measurements that were of limited utility. Advances in physiology and engineering allowed Einthoven to construct a device that was uniquely capable of recording the minute electrical currents of the heart.
View Article and Find Full Text PDFCell Rep Med
January 2025
Ben May Department for Cancer Research, The University of Chicago, Chicago, IL 60637, USA. Electronic address:
Metabolic reprogramming of tumor cells is an emerging hallmark of cancer. Among all the changes in cancer metabolism, increased glucose uptake and the accumulation of lactate under normoxic conditions (the "Warburg effect") is a common feature of cancer cells. In this study, we develop a lactate-responsive drug delivery platform by targeting the Warburg effect.
View Article and Find Full Text PDFTalanta
January 2025
Key Laboratory for Advanced Materials, Joint International Research Laboratory for Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, PR China. Electronic address:
Hypochlorous acid (HClO/ClO) is a common ROS that exhibits elevated activity levels in cancer cells. In this study, an ClO-triggered TADF probe, PTZ-MNI, was designed based on a naphthalimide core. PTZ-MNI self-assemble in aqueous environments, exhibiting significantly enhanced fluorescence that demonstrated typical aggregation-induced delayed fluorescence (AIDF) characteristics.
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