AI Article Synopsis
- Peptides, like Hym-301 found in hydra, are important signaling molecules involved in cell activities and morphogenesis.
- The study explores the intracellular localization of Hym-301 using advanced imaging techniques, revealing its unique distribution compared to its mRNA.
- Hym-301 is stored in vesicles near the cell membrane and is released both outside the cell and into the cytoplasm, leading to a proposed model for its regulatory role in tissue dynamics.
Article Abstract
Peptides, as signaling molecules, play a number of roles in cell activities. An epitheliopeptide, Hym-301, has been described as a peptide involved in morphogenesis in hydra. However, little is known about the intracellular location of the peptide or its specific functions. To investigate the mechanism of morphogenesis that involves peptidic molecules, we have examined the intracellular localization of Hym-301 in hydra by using immunohistochemical and immunogold electron-microscopic analyses. We have found that the pattern of distribution of mature peptide is slightly different from that of its mRNA, and that the peptide is stored in vesicles located adjacent to the cell membrane. We have also found that the peptide is released both extracellularly and internally to the cytoplasm of the cells. Based upon these observations, we have constructed a possible model mechanism of homeostatic regulation of the distribution of the Hym-301 peptide in a dynamic tissue context.
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| http://dx.doi.org/10.1007/s00441-012-1527-0 | DOI Listing |
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