In the analysis of dependencies between nominal traits entropy and its function, mutual information seems to be a proper descriptive statistic. This is shown by characterizing the relationships between the prolificacy of dams and selected genetic attributes: the genotype of transferrin, the genotype of hemoglobin, and the type of birth, as well as the environmental attribute, i.e., year of birth. The entropy method may improve the exactitude of investigations concerning the influence of different factors on production trait. The index of relative uniformity, introduced in this study, proved to be an adequate tool for the determination of similarity in the examined flocks. The application of mutual information in the determination of values of the dependence measures in the analyzed experiment was justified.
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http://dx.doi.org/10.1007/s13353-012-0123-z | DOI Listing |
Circ Res
December 2024
Cardiovascular Research Center, Massachusetts General Hospital, Boston. (C.C., P.X., Z.Y., Y.S., E.S.L., J.D.R., M.C.H.).
Background: Preeclampsia is a hypertensive disorder of pregnancy characterized by systemic endothelial dysfunction. The pathophysiology of preeclampsia remains incompletely understood. This study used human venous endothelial cell (EC) transcriptional profiling to investigate potential novel mechanisms underlying EC dysfunction in preeclampsia.
View Article and Find Full Text PDFJ Dent Res
December 2024
Department of Pediatric Dentistry and Dental Public Health, Adams School of Dentistry, University of North Carolina at Chapel Hill, NC, USA.
Early childhood caries (ECC) is the most common noncommunicable childhood disease-an important health problem with known environmental and social/behavioral influences lacking consensus genetic risk loci. To address this knowledge gap, we conducted a genome-wide association study of ECC in a multiancestry population of U.S.
View Article and Find Full Text PDFRecent studies have revealed a role for zinc in insulin secretion and glucose homeostasis. Randomized placebo-controlled zinc supplementation trials have demonstrated improved glycemic traits in patients with type II diabetes (T2D). Moreover, rare loss-of-function variants in the zinc efflux transporter reduce T2D risk.
View Article and Find Full Text PDFNeuroendocrinology
December 2024
Background: Thyroid hormones play a critical role in brain development. However, the precise causal associations between thyroid function and structural changes in specific brain regions remain uncertain.
Methods: We applied the univariate Mendelian randomization (UVMR) method to assess the causal effects of thyroid function on brain structure.
medRxiv
November 2024
RTI International, Research Triangle Park, NC.
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