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Biochemical Mechanisms and Rehabilitation Strategies in Osteoporosis-Related Pain: A Systematic Review.
Clin Pract
December 2024
Department of Experimental Medicine (Di.Me.S), University of Salento, 73100 Lecce, Italy.
Background/objectives: Osteoporosis causes a bone mass reduction and often determines acute and chronic pain. Understanding the biochemical and neurophysiological mechanisms behind this pain is crucial for developing new, effective rehabilitative and therapeutic approaches. This systematic review synthesizes recent advances in muscle-bone interactions and molecular pathways related to osteoporosis-associated pain.
View Article and Find Full Text PDFEffects of climate change on the occurrence and distribution of Western equine encephalitis virus in South America.
Public Health
December 2024
Department of Epidemiology, School of Public Health, University of Sao Paulo, Av. Dr. Arnaldo, 715, CEP 05509-300, São Paulo, SP, Brazil.
Objectives: The Western equine encephalitis virus (WEEV) is a globally relevant vector-borne pathogen that causes encephalitis. The role of environmental variables in the epidemiology of WEEV has become greater in the context of climate change. In December 2023, a significant resurgence of WEEV began in South America, with major ongoing outbreaks in Argentina and Uruguay.
View Article and Find Full Text PDFThe modulating role of uniaxial straining in the IL-1β and TGF-β mediated inflammatory response of human primary ligamentocytes.
Front Bioeng Biotechnol
December 2024
Karl Chiari Lab for Orthopaedic Biology, Department of Orthopedics and Trauma Surgery, Medical University of Vienna, Vienna, Austria.
Biomechanical (over-)stimulation, in addition to inflammatory and fibrotic stimuli, severely impacts the biology, contributing to the overall chronic nature of desmopathy. A major challenge has been the lack of representative two-dimensional (2D) models mimicking inflammatory processes in the presence of dynamic mechanical strain, both being crucial for ligament homeostasis. Physiological levels of strain exert anti-inflammatory effects, while excessive strain can facilitate inflammatory mechanisms.
View Article and Find Full Text PDFGastrointestinal jumbo phages possess independent synthesis and utilization systems of NAD.
Microbiome
December 2024
College of Life Sciences, Shihezi University, Shihezi, Xinjiang, 832003, China.
Article Synopsis
- Jumbo phages are large viruses with genomes over 200 kbp, and little is known about their life cycle and unique reproductive genes.
- Researchers assembled 668 high-quality jumbo phage genomes from 955 samples of various animal species and identified the largest known phage genome at 716 kbp, revealing they can synthesize NAD and contain numerous NAD-consuming enzymes.
- The study highlights the widespread presence of NAD-jumbo phages in different ecosystems, emphasizing the need for further research on their ecological roles and survival strategies.
Objective: To describe indications for and demonstrate the technique to perform a transtracheal aspirate in horses. Transtracheal aspirate is indicated to collect samples for cytology and bacteriologic culture in cases of suspected pneumonia or other lower respiratory tract disease.
Animals: 1 healthy university-owned horse was used for demonstration purposes.
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