The properties of glycine receptors (GlyRs) depend upon their subunit composition. While the prevalent adult forms of GlyRs are heteromers, previous reports suggested functional α homomeric receptors in mature nervous tissues. Here we show two functionally different GlyRs populations in the rat medial nucleus of trapezoid body (MNTB). Postsynaptic receptors formed α1/β-containing clusters on somatodendritic domains of MNTB principal neurons, colocalizing with glycinergic nerve endings to mediate fast, phasic IPSCs. In contrast, presynaptic receptors on glutamatergic calyx of Held terminals were composed of dispersed, homomeric α1 receptors. Interestingly, the parent cell bodies of the calyces of Held, the globular bushy cells of the cochlear nucleus, expressed somatodendritic receptors (α1/β heteromers) and showed similar clustering and pharmacological profile as GlyRs on MNTB principal cells. These results suggest that specific targeting of GlyR β-subunit produces segregation of GlyR subtypes involved in two different mechanisms of modulation of synaptic strength.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531607 | PMC |
| http://dx.doi.org/10.1523/JNEUROSCI.1547-12.2012 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Maintenance of a central high frequency synapse in the absence of synaptic activity.
Front Cell Neurosci
November 2024
Department of Functional Neuroanatomy, Institute of Anatomy and Cell Biology, Heidelberg University, Heidelberg, Germany.
Activity has long been considered essential for circuit formation and maintenance. This view has recently been challenged by proper synaptogenesis and only mildly affected synapse maintenance in the absence of synaptic activity in forebrain neurons. Here, we investigated whether synaptic activity is necessary for the development and maintenance of the calyx of Held synapse.
View Article and Find Full Text PDFLoss of C1q alters the auditory brainstem response.
Front Cell Neurosci
October 2024
Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA, United States.
Neural circuits in the auditory brainstem compute interaural time and intensity differences used to determine the locations of sound sources. These circuits display features that are specialized for these functions. The projection from the ventral cochlear nucleus (VCN) to the medial nucleus of the trapezoid (MNTB) body travels along highly myelinated fibers and terminates in the calyx of Held.
View Article and Find Full Text PDFIntersectin-1 enhances calcium-dependent replenishment of the readily releasable pool of synaptic vesicles during development.
J Physiol
October 2024
Neurosciences and Mental Health, SickKids Research Institute, Toronto, Ontario, Canada.
Article Synopsis
- Intersectin-1 (Itsn1) is a protein that helps with sending and receiving signals in the brain, especially in a part called the calyx of Held synapse.
- Researchers looked at mice with and without Itsn1 to see how it affected their hearing and signal transmission as they grew up.
- They found Itsn1 is really important for helping the synapse work well, especially in mature mice, as it helps replenish the resources needed for sending signals quickly after they’ve been used.
Protocol for VIVALDI social care: Pilot study to reduce infections, outbreaks and antimicrobial resistance in care homes for older adults.
NIHR Open Res
February 2024
University College London, London, England, WC1E 6BT, UK.
Care home residents are vulnerable to severe outcomes from infections such as COVID-19 and influenza. However, measures to control outbreaks, such as care home closures to visitors and new admissions, have a detrimental impact on their quality of life. Many infections and outbreaks could be prevented but the first step is to measure them reliably.
View Article and Find Full Text PDF15-Gene Expression Profile and as Integrated Prognostic Test for Uveal Melanoma: First Report of Collaborative Ocular Oncology Group Study No. 2 (COOG2.1).
J Clin Oncol
October 2024
Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX.
PURPOSEValidated and accurate prognostic testing is critical for precision medicine in uveal melanoma (UM). Our aims were to (1) prospectively validate an integrated prognostic classifier combining a 15-gene expression profile (15-GEP) and RNA expression and (2) identify clinical variables that enhance the prognostic accuracy of the 15-GEP/ classifier.MATERIALS AND METHODSThis study included 1,577 patients with UM of the choroid and/or ciliary body who were enrolled in the Collaborative Ocular Oncology Group Study Number 2 (COOG2) and prospectively monitored across 26 North American centers.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!