AI Article Synopsis
- In the past two decades, research has increasingly connected the MLL1 gene to various acute and myelogenous leukemias.
- MLL1 is integral to regulating gene expression during development and belongs to the SET1 family of lysine methyltransferases.
- The review highlights recent findings about the structure and function of MLL1 regulatory proteins (MRPs) and explores new frameworks for understanding how MLL1 activity is regulated.
Article Abstract
In the last 20 years, we have witnessed an exponential number of evidences linking the human mixed lineage leukemia-1 (MLL1) gene to several acute and myelogenous leukemias. MLL1 is one of the founding members of the SET1 family of lysine methyltransferases and is key for the proper control of developmentally regulated gene expression. MLL1 is a structurally complex protein composed of several functional domains. These domains play pivotal roles for the recruitment of regulatory proteins. These MLL1 regulatory proteins (MRPs) dynamically interact with MLL1 and consequently control gene expression. In this review, we summarize recent structural and functional studies of MRPs and discuss emergent structural paradigms for the control of MLL1 activity.
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| http://dx.doi.org/10.1002/bip.22126 | DOI Listing |
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