The Weinreb amides 2a,b were prepared from the α,α-dimethoxyacetic acids 1c,d. A number of representative nucleophilic additions (RMgX and RLi) on 2 afforded α-ketoacetals 3a-j in 70-99% yield. These compounds represent a versatile arrangement of functional groups of significant synthetic value, as demonstrated in the synthesis of (±)-salbutamol.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268805 | PMC |
| http://dx.doi.org/10.3390/molecules171213864 | DOI Listing |
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