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The Effect of Preinduction Cervical Ripening With Synthetic Hygroscopic Dilators on Maternal Outcomes of Women With Previous Caesarean Pregnancy: A Single-Group Clinical Trial.
J Pregnancy
December 2024
Department of Preventive and Social Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.
Preinduction cervical ripening in previous caesarean pregnancy is limited to intracervical Foley catheter. This study is aimed at finding the vaginal birth rates, improvement of Bishop score, and safety of osmotic dilator (Dilapan-S) among women with previous caesarean pregnancy. We conducted this single-group clinical study after the approval of the institute ethics committee, clinical trial registration, and obtaining informed consent.
View Article and Find Full Text PDFOxytocin-mediated social preference and socially reinforced reward learning in the miniature fish Danionella cerebrum.
Curr Biol
December 2024
Department of Neurobiology, University of Utah, 20 S 2030 E, BPRB 490D, Salt Lake City, UT 84112, USA. Electronic address:
Integrative studies of diverse neuronal networks that govern social behavior are hindered by a lack of methods to record neural activity comprehensively across the entire brain. The recent development of the miniature fish Danionella cerebrum as a model organism offers one potential solution, as the small size and optical transparency of these animals make it possible to visualize circuit activity throughout the nervous system. Here, we establish the feasibility of using Danionella as a model for social behavior and socially reinforced learning by showing that adult fish exhibit strong affiliative tendencies and that social interactions can serve as the reinforcer in an appetitive conditioning paradigm.
View Article and Find Full Text PDFImpact of chronic intranasal oxytocin administration on face expression processing in autistic children: a randomized controlled trial using fMRI.
Mol Autism
December 2024
Department of Neurosciences, Center for Developmental Psychiatry, KU Leuven, Leuven, Belgium.
Background: Difficulties with (non-verbal) social communication, including facial expression processing, constitute a hallmark of autism. Intranasal administration of oxytocin has been considered a potential therapeutic option for improving social difficulties in autism, either by enhancing the salience of social cues or by reducing the social stress and anxiety experienced in social encounters.
Methods: We recorded fMRI brain activity while presenting neutral, fearful and scrambled faces, to compare the neural face processing signature of autistic children (n = 58) with that of matched non-autistic controls (n = 38).
Physiological welfare indicators in wild cetaceans: Epidermal cortisol and oxytocin concentrations in stranded striped dolphins.
Comp Biochem Physiol A Mol Integr Physiol
December 2024
Department of Animal and Food Science, School of Veterinary Science, Universitat Autònoma de Barcelona, Bellaterra, Spain; Animal Welfare Education Centre (AWEC), School of Veterinary Science, Universitat Autònoma de Barcelona, Bellaterra, Spain.
Anthropogenic pressures and climate change present growing challenges for cetaceans, as the combined effects of multiple stressors can jeopardize their welfare and survival. In this context, validating reliable individual welfare indicators is crucial for quantifying these impacts. This study aimed to validate a method for measuring cortisol and oxytocin from the epidermis of stranded striped dolphins (Stenella caeruleoalba) using enzyme immunoassays, while accounting for confounding factors such as epidermal layer and body location.
View Article and Find Full Text PDFHormonal mechanisms in the paraventricular nuclei associated with hyperalgesia in Parkinson's disease model rats.
Biochem Biophys Res Commun
December 2024
Department of Dental Anesthesiology, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka, 565-0871, Japan. Electronic address:
Pain is a major non-motor symptom of Parkinson's disease (PD). The relationship between hyperalgesia and neuropeptides originating from paraventricular nucleus (PVN) in 6-hydroxydopamine (6-OHDA) rats has already been investigated for oxytocin (OXT), but not yet for arginine vasopressin (AVP) and corticotropin-releasing hormone (CRH). The present study aimed to investigate the alterations in these neuropeptides following nociceptive stimulation in PD model rats and to examine the mechanisms of hyperalgesia.
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