Background: To investigate whether or not coadministration of tacrolimus (TAC) with prednisolone (PSL) can produce a beneficial effect in the treatment of polymyositis/ dermatomyositis (PM/DM).
Methods: We reviewed medical records of 32 PM/DM patients who had been admitted to our hospital, and abstracted those who had received TAC in addition to oral PSL for treatment. The clinical usefulness of TAC in PM/DM was objectively evaluated focusing upon the manual muscle strength test (MMT) score, serum creatine kinase (CK) and tapering of PSL.
Results: Nine patients with PM and 6 with DM were enrolled in this study. TAC was added because of difficulty in reduction of PSL in 12 patients and recurrence with corticosteroid-induced complications in the remaining 3. Both PM and DM patients showed significant increases in the MMT score and significant decreases in serum CK 1 to 3 months after starting TAC compared with before. Skin symptoms in a clinically amyopathic DM patient also improved 1 month after starting TAC. The daily dosage of PSL could be significantly reduced in both PM and DM after starting TAC compared with before. No serious adverse events ascribable to TAC occurred in any patients.
Conclusion: Additional use of TAC with PSL may safely promote improvement of PM/DM and also accelerate tapering of the latter.
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http://dx.doi.org/10.1186/1471-2474-13-228 | DOI Listing |
Sci Rep
November 2024
Laboratory of Tropical Ecology, University of Sciences, Techniques and Technologies of Bamako, BP: E 3206, Bamako, Mali.
Acridocarpus monodii Arène & Jaeger is an endemic plant species to the ''Dogon Country'' in Mali. This species is highly popular in Dogon ethnic groups, but no scientific data on its medicinal and biochemical properties are available in Mali. This work aimed to list its medicinal uses and assess its phytochemical composition and antioxidant power.
View Article and Find Full Text PDFNutr Metab (Lond)
November 2024
Univ Rennes, M2S (Laboratoire Mouvement, Sport, Santé), Rennes, EA 1274, F-35000, France.
Supplementing with antioxidants may be one of the most efficient means of minimizing oxidative stress during workouts in obese individuals. The aim of this study is to identify the results after twelve weeks of CrossFit workouts combined with Spinach thylakoid extract on the levels of insulin resistance (insulin and Homeostatic Model Assessment of Insulin Resistance [HOMA-IR]), fasting blood sugar (FBS), malondialdehyde (MDA), creatine kinase (CK), lactate dehydrogenase (LDH), total antioxidant capacity (TAC), and superoxide dismutase (SOD), glutathione peroxidase (GPx) in obese males. Sixty-eight males with an average age of 27 ± 8 yrs and a BMI of 32.
View Article and Find Full Text PDFMolecules
September 2024
Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, Coopers Plains, QLD 4108, Australia.
Domestic storage conditions can have a significant impact on the composition of phytochemicals and sugars in stone fruits. This study aimed to evaluate the effect of two domestic storage temperatures (4 and 23 °C) on the physicochemical properties, phytochemical composition, and sugars of 'Rubycot' (RC) plumcot, a novel stone fruit variety, and 'Queen Garnet' (QG) plum. Initially, RC had a lower total anthocyanin concentration (TAC) than QG, but TAC in RC increased significantly ( < 0.
View Article and Find Full Text PDFFront Pharmacol
September 2024
Nephrology Department, Hospital Universitari de Bellvitge-IDIBELL, Barcelona, Spain.
Aims: The once-daily extended-release tacrolimus formulation (ER-Tac) has demonstrated similar efficacy and safety to the twice-daily immediate-release formulation (IR-Tac), but few population-based pharmacokinetic models have been developed in kidney transplant patients to optimize doses. Therefore, this study aimed i) at developing a population pharmacokinetic model for ER-Tac in adult kidney transplant patients ii) and identifying genetic factors and time-varying covariates predictive of pharmacokinetic variability to guide tacrolimus dosage during the early post-transplant period.
Methods: A total of 1,067 blood tacrolimus concentrations from 138 kidney transplant patients were analyzed.
Tissue Cell
December 2024
Department of Biology, Faculty of Science, Arak University, Arak 3848177584, Iran.
Ovarian tissue autografting is a valuable clinical option to help restore fertility in women with cancer. However, many follicles are lost due to ischemia-reperfusion (IR) injury, which depletes follicles after grafting. We aimed to investigate the effect of vitamin C, an antioxidant with anti-apoptotic and anti-inflammatory properties, on improving the structure and function of autografted ovaries in mice.
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