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Rationale and Logistics of Continuous Infusion Cephalosporin Antibiotics.
Pharmacy (Basel)
December 2024
Department of Pharmacy, Prisma Health Richland, 5 Medical Park Drive, Columbia, SC 29203, USA.
Cephalosporins have traditionally been administered as an intermittent infusion. With the knowledge that cephalosporins demonstrate a time-dependent pharmacodynamic profile, administration via continuous infusion may provide more effective antibiotic exposure for successful therapy. Proposed benefits of administration via continuous infusion include less IV manipulation, decreased potential for antibiotic resistance, and potential cost savings.
View Article and Find Full Text PDFProlonged vs Intermittent Infusions of β-Lactam Antibiotics-Reply.
JAMA
December 2024
University of Queensland Centre for Clinical Research (UQCCR), The University of Queensland, Brisbane, Queensland, Australia.
Prolonged vs Intermittent Infusions of β-Lactam Antibiotics.
JAMA
December 2024
Department of Gastrointestinal Cancer Center, Chongqing University Cancer Hospital, Chongqing, China.
Enhanced Fear Extinction Through Infralimbic Perineuronal Net Digestion: The Modulatory Role of Adolescent Alcohol Exposure.
Alcohol
December 2024
Department of Neuroscience, Medical University of South Carolina, Charleston, SC 29425; Department of Anesthesiology and Perioperative Medicine, Medical University of South Carolina, Charleston, SC 29425. Electronic address:
Perineuronal nets (PNNs) are specialized components of the extracellular matrix that play a critical role in learning and memory. In a Pavlovian fear conditioning paradigm, degradation of PNNs affects the formation and storage of fear memories. This study examined the impact of adolescent intermittent ethanol (AIE) exposure by vapor inhalation on the expression of PNNs in the adult rat prelimbic (PrL) and infralimbic (IfL) subregions of the medial prefrontal cortex.
View Article and Find Full Text PDFEffects of continuous pecto-intercostal fascial block for management of post-sternotomy pain in patients undergoing cardiac surgery: a randomized controlled trial.
Int J Surg
December 2024
Department of Anesthesiology, Xiangya Hospital of Central South University, Changsha, Hunan Province, China.
Background: Managing postoperative pain following median sternotomy has long been a notable challenge for anesthesiologists. The administration of postoperative analgesia traditionally relies on intravenous pumps for the delivery of opioids. With the development of regional block techniques and postoperative multimodal analgesia, pecto-intercostal fascial block (PIFB) has gained widespread utilization due to its distinctive advantages.
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