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Results of the two incidence screenings in the National Lung Screening Trial.
N Engl J Med
September 2013
Department of Radiological Sciences, David Geffen School of Medicine at the University of California at Los Angeles (UCLA), Los Angeles, CA 90024, USA.
Background: The National Lung Screening Trial was conducted to determine whether three annual screenings (rounds T0, T1, and T2) with low-dose helical computed tomography (CT), as compared with chest radiography, could reduce mortality from lung cancer. We present detailed findings from the first two incidence screenings (rounds T1 and T2).
Methods: We evaluated the rate of adherence of the participants to the screening protocol, the results of screening and downstream diagnostic tests, features of the lung-cancer cases, and first-line treatments, and we estimated the performance characteristics of both screening methods.
Reduced lung-cancer mortality with low-dose computed tomographic screening.
N Engl J Med
August 2011
Background: The aggressive and heterogeneous nature of lung cancer has thwarted efforts to reduce mortality from this cancer through the use of screening. The advent of low-dose helical computed tomography (CT) altered the landscape of lung-cancer screening, with studies indicating that low-dose CT detects many tumors at early stages. The National Lung Screening Trial (NLST) was conducted to determine whether screening with low-dose CT could reduce mortality from lung cancer.
View Article and Find Full Text PDFThe National Lung Screening Trial: overview and study design.
Radiology
January 2011
Center for Statistical Sciences, Brown University, Box G-S121, 121 S Main St, 7th Floor, Providence, RI 02912, USA.
The National Lung Screening Trial (NLST) is a randomized multicenter study comparing low-dose helical computed tomography (CT) with chest radiography in the screening of older current and former heavy smokers for early detection of lung cancer, which is the leading cause of cancer-related death in the United States. Five-year survival rates approach 70% with surgical resection of stage IA disease; however, more than 75% of individuals have incurable locally advanced or metastatic disease, the latter having a 5-year survival of less than 5%. It is plausible that treatment should be more effective and the likelihood of death decreased if asymptomatic lung cancer is detected through screening early enough in its preclinical phase.
View Article and Find Full Text PDFBest cases from the AFIP: multiple gastric carcinoids.
Radiographics
September 2009
Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S Kingshighway Blvd, St Louis, MO 63110, USA.
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