AI Article Synopsis
- Connexins play a significant role in regulating cell migration and proliferation during brain development, but their postnatal functions are not well understood.
- Overexpression of connexin 45 (Cx45) in postnatal precursor cells increased their proliferation, while its deletion reduced proliferation.
- Cx45 promotes cell cycle reentry through ATP signaling, which involves intracellular calcium and ERK1/2 signaling pathways.
Article Abstract
Connexins have been implicated in the regulation of precursor cell migration and proliferation during embryonic development of the mammalian brain. However, their function in postnatal neurogenesis is unclear. Here we demonstrate that connexin (Cx) 45 is expressed in transit-amplifying cells and neuroblasts in the postnatal subventricular zone (SVZ) and modulated the proliferation of SVZ-derived precursor cells in vivo. Thus, overexpression of Cx45 by retroviral injections increased the proliferation of Mash-1-positive transit-amplifying precursor cells in the SVZ. Conversely, conditional deletion of Cx45 in precursor cells decreased proliferation. Finally, we established that Cx45 positively influences cell cycle reentry via ATP signaling that involves intracellular calcium stores and ERK1/2 signaling.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523819 | PMC |
| http://dx.doi.org/10.1073/pnas.1217103109 | DOI Listing |
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