A common statistical problem is to make inference about the mean of a normally distributed population. While the mean and the variance are important quantities, many real problems require information on certain quantiles of the population which combine both the mean and variance. Motivated by two recent applications, we consider simultaneous inference for more than one quantile of interest. In this paper, a set of exact 1-α level simultaneous confidence intervals for several quantiles of a normally distributed population is constructed, based on a simple random sample from that population. The critical constants for achieving an exact 1-α simultaneous coverage probability can be computed efficiently using numerical quadrature involving only a one-dimensional integral combined with standard search algorithms. The proposed methods are illustrated with an example. Several further research problems are identified.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1002/bimj.201100232 | DOI Listing |
J Integr Neurosci
January 2025
Neuroscience Department, University of Connecticut Health, School of Medicine, Institute for Systems Genomics, Farmington, CT 06030, USA.
Background: In neuroscience, Ca imaging is a prevalent technique used to infer neuronal electrical activity, often relying on optical signals recorded at low sampling rates (3 to 30 Hz) across multiple neurons simultaneously. This study investigated whether increasing the sampling rate preserves critical information that may be missed at slower acquisition speeds.
Methods: Primary neuronal cultures were prepared from the cortex of newborn pups.
Biology (Basel)
January 2025
Department of Bioinformatics, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.
To date, standard rRNA marker genes have had limited success in resolving the phylogeny of the phylum Chytridiomycota. Whereas the conserved and easily alignable ribosomal small subunit 18S rRNA gene had problems resolving nodes relating orders, the internal transcribed spacer 2 (ITS2) has been claimed to not be alignable for this group of organisms. Although the ITS2 is a fast-evolving locus, its secondary structure is well conserved.
View Article and Find Full Text PDFVaccines (Basel)
January 2025
Vaccine and Infectious Diseases Organization (VIDO), University of Saskatchewan, Saskatoon, SK S7N 5A2, Canada.
Adjuvants are a diverse group of substances that can be added to vaccines to enhance antigen-specific immune responses and improve vaccine efficacy. The first adjuvants, discovered almost a century ago, were soluble crystals of aluminium salts. Over the following decades, oil emulsions, vesicles, oligodeoxynucleotides, viral capsids, and other complex organic structures have been shown to have adjuvant potential.
View Article and Find Full Text PDFPLoS Comput Biol
January 2025
Department of Quantitative and Computational Biology, University of Southern California, Los Angeles, California, United States of America.
Biological systems exhibit complex dynamics that differential equations can often adeptly represent. Ordinary differential equation models are widespread; until recently their construction has required extensive prior knowledge of the system. Machine learning methods offer alternative means of model construction: differential equation models can be learnt from data via model discovery using sparse identification of nonlinear dynamics (SINDy).
View Article and Find Full Text PDFUnlabelled: Calcium imaging is a key method to record the spiking activity of identified and genetically targeted neurons. However, the observed calcium signals are only an indirect readout of the underlying electrophysiological events (single spikes or bursts of spikes) and require dedicated algorithms to recover the spike rate. These algorithms for spike inference can be optimized using ground truth data from combined electrical and optical recordings, but it is not clear how such optimized algorithms perform on cell types and brain regions for which ground truth does not exist.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!