AI Article Synopsis
- Acral pseudolymphomatous angiokeratoma of children (APACHE) presents as multiple red papules primarily on the hands and feet in affected children.
- A case study followed a female patient from ages 13 to 19, noting a dark red lesion on her thigh with specific histological features indicating lymphocyte involvement and cellular infiltration beneath the skin surface.
- Immunolabeling showed the lesion's blood vessels were positive for markers indicating both lymphatic and blood vessels, suggesting APACHE is a vascular malformation.
Article Abstract
Acral pseudolymphomatous angiokeratoma of children (APACHE) is characterized by multiple angiomatous papules on the hands and feet in children. Here, we report a case of APACHE in a female patient followed up from 13 to 19 years of age with a dark red lesion on the center of the dorsum of the right thigh. Histologically, vacuolar alteration and exocytosis of lymphocytes, and specific dense cellular infiltration beneath the epidermis to the reticular dermis were found. On immunolabeling study, the lesion vessels were found to be positive for both the lymphatic endothelium-specific marker podoplanin and blood vessel-specific marker CD34. These findings suggested that APACHE is a type of vascular malformation.
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| http://dx.doi.org/10.1097/DAD.0b013e31824d679e | DOI Listing |
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