Background: Intracerebroventricular infusion of NaHS, a hydrogen sulfide (H(2)S) donor, increased mean arterial pressure (MAP). This study was designed to determine the roles of H(2)S in the paraventricular nucleus (PVN) in modulating sympathetic activity and cardiac sympathetic afferent reflex (CSAR) in chronic heart failure (CHF).
Methodology/principal Findings: CHF was induced by left descending coronary artery ligation in rats. Renal sympathetic nerve activity (RSNA) and MAP were recorded under anesthesia. CSAR was evaluated by the RSNA and MAP responses to epicardial application of capsaicin. PVN microinjection of low doses of a H(2)S donor, GYY4137 (0.01 and 0.1 nmol), had no significant effects on RSNA, MAP and CSAR. High doses of GYY4137 (1, 2 and 4 nmol) increased baseline RSNA, MAP and heart rate (HR), and enhanced CSAR. The effects were greater in CHF rats than sham-operated rats. A cystathionine-β-synthase (CBS) inhibitor, hydroxylamine (HA) in PVN had no significant effect on the RSNA, MAP and CSAR. CBS activity and H(2)S level in the PVN were decreased in CHF rats. No significant difference in CBS level in PVN was found between sham-operated rats and CHF rats. Stimulation of cardiac sympathetic afferents with capsaicin decreased CBS activity and H(2)S level in the PVN in both sham-operated rats and CHF rats.
Conclusions: Exogenous H(2)S in PVN increases RSNA, MAP and HR, and enhances CSAR. The effects are greater in CHF rats than those in sham-operated rats. Endogenous H(2)S in PVN is not responsible for the sympathetic activation and enhanced CSAR in CHF rats.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499499 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0050102 | PLOS |
Publication Analysis
Top Keywords
Similar Publications
Image-guided Interventions for Core Muscle Injury and Other Disorders in the Pubic Symphysis.
Radiographics
February 2025
Department of Medical Imaging, The Ottawa Hospital, 501 Smyth Rd, Ottawa, ON, Canada K1H 8L6 (D.V.F., J.L.); Department of Radiology, Radiation Oncology and Medical Physics, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada (D.V.F., J.L.); Ottawa Hospital Research Institute, Ottawa, Ontario, Canada (D.V.F., J.L.); and Department of Radiology, St. Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada (T.M.).
Formerly termed or , core muscle injury (CMI) encompasses abnormality of structures within the so-called core, which is essentially the hip, abdomen, and pubis. Compared with data on image-guided procedures of other joints, information regarding procedures performed to address CMI and other disorders of the pubic symphysis is lacking. These procedures can be daunting given the joint's small size, surrounding critical neurovascular structures, and three-dimensional anatomy.
View Article and Find Full Text PDFF-FLT PET and Blood-based Biomarkers for Identifying Gastrointestinal Graft versus Host Disease after Allogeneic Cell Transplantation.
Radiol Imaging Cancer
January 2025
From the Stephenson Cancer Center, University of Oklahoma Health Sciences Center, 800 NE 10th St, Oklahoma City, OK 73104 (J.H.C., L.M., S.K.V., Z.H., M.P., J.G., Y.W.); Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY (J.L., J.F.); Department of Biostatistics and Epidemiology, Hudson College of Public Health, The University of Oklahoma, Oklahoma City, Okla (S.K.V., T.G.); Experimental Transplantation and Immunotherapy Branch, National Cancer Institute, National Institutes of Health, Bethesda, Md (C.G.K., R.G.); Department of Biomedical Engineering, University of Central Oklahoma, Edmond, Okla (Z.H.); and Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Emory University, Atlanta, GA (K.M.W.).
Purpose To determine whether fluorine 18 (F) fluorothymidine (FLT) PET imaging alone or combined with Mount Sinai Acute GVHD International Consortium (MAGIC) biomarkers could help identify subclinical gastrointestinal graft versus host disease (GI-GVHD) by day 100 following hematopoietic stem cell transplantation (HSCT). Materials and Methods F-FLT PET imaging was analyzed in a prospective pilot study (ClinicalTrials.gov identifier no.
View Article and Find Full Text PDFEvaluating the Cumulative Benefit of Inspiratory CT, Expiratory CT, and Clinical Data for COPD Diagnosis and Staging through Deep Learning.
Radiol Cardiothorac Imaging
December 2024
From the Computational Science Research Center, San Diego State University, San Diego, Calif (A.N.L.); Department of Radiology, University of California San Diego, La Jolla, Calif (A.H.); and Department of Mathematics and Statistics, San Diego State University, 5500 Campanile Dr, San Diego, CA 92182 (K.A.H.).
Purpose To measure the benefit of single-phase CT, inspiratory-expiratory CT, and clinical data for convolutional neural network (CNN)-based chronic obstructive pulmonary disease (COPD) staging. Materials and Methods This retrospective study included inspiratory and expiratory lung CT images and spirometry measurements acquired between November 2007 and April 2011 from 8893 participants (mean age, 59.6 years ± 9.
View Article and Find Full Text PDFMechanical circulatory support reduces renal sympathetic nerve activity in an ovine model of acute myocardial infarction.
Clin Auton Res
November 2024
Manaaki Manawa - The Centre for Heart Research and the Department of Physiology, University of Auckland, New Zealand, Auckland, New Zealand.
Purpose: The use of circulatory assist devices has been shown to improve glomerular filtration rate and reduce the incidence of acute kidney injury in patients following acute cardiac pathology. However, the mechanisms of improvement in kidney function are not clear. We tested the hypothesis that mechanical circulatory support would result in a decrease in directly recorded renal sympathetic nerve activity (RSNA) and mediate the improvement in renal blood flow (RBF) in a setting of acute myocardial infarction (AMI)-induced left ventricular systolic dysfunction.
View Article and Find Full Text PDFMinimally interactive segmentation of soft-tissue tumors on CT and MRI using deep learning.
Eur Radiol
November 2024
Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.
Background: Segmentations are crucial in medical imaging for morphological, volumetric, and radiomics biomarkers. Manual segmentation is accurate but not feasible in clinical workflow, while automatic segmentation generally performs sub-par.
Purpose: To develop a minimally interactive deep learning-based segmentation method for soft-tissue tumors (STTs) on CT and MRI.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!