Telaprevir to boceprevir switch highlights lack of cross-reactivity.

Clin Infect Dis

Department of Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA.

Published: February 2013

Hepatitis C viral protease inhibitors increase sustained virologic response rates compared to interferon and ribavirin but also add side effects. Telaprevir and boceprevir are structurally similar, and share cross-resistant mutations. This case report highlights successful management of telaprevir skin rash and anal discomfort by switching to boceprevir.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732052PMC
http://dx.doi.org/10.1093/cid/cis960DOI Listing

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