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Proteopedia: 3D visualization and annotation of transcription factor-DNA readout modes. | LitMetric
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Proteopedia: 3D visualization and annotation of transcription factor-DNA readout modes.

Ana Carolina Dantas Machado Skyler B Saleebyan Bailey T Holmes Maria Karelina Julia Tam Sharon Y Kim Keziah H Kim Iris Dror Eran Hodis Eric Martz Patricia A Compeau Remo Rohs

Biochem Mol Biol Educ

Molecular and Computational Biology Program, Departments of Biological Sciences, Chemistry, and Physics and Astronomy, University of Southern California, 1050 Childs Way, Los Angeles, CA 90089, USA.

Published: May 2013

3D visualization assists in identifying diverse mechanisms of protein-DNA recognition that can be observed for transcription factors and other DNA binding proteins. We used Proteopedia to illustrate transcription factor-DNA readout modes with a focus on DNA shape, which can be a function of either nucleotide sequence (Hox proteins) or base pairing geometry (p53). © 2012 by The International Union of Biochemistry and Molecular Biology.

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http://dx.doi.org/10.1002/bmb.20650DOI Listing

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