Background: Prophylactic neck dissection (PND) is indicated when the chance of occult lymph node metastases from head and neck tumors is significant. There is no consensus regarding which tumor size PND would be indicated in cases of lip cancer.
Methods: A total of 139 patients with surgically treated lip cancer were selected. The size of the lesion (T) and the presence of lymph node metastases (N) were assessed by examining the medical records. For analysis purposes, the T2 group was divided into T2a (2 to 3 cm) and T2b (3 to 4 cm).
Results: The following distribution of incidence of neck metastases was observed in the study groups: 11.7% in T1, 9% in T2a, 43.7% in T2b, and 52.2% in T3+T4. Statistical comparison of the groups (p) revealed the following results: T2aXT2b=0.03; T2aXT3+T4=0.001.
Conclusion: PND is indicated for tumors larger than 3 cm.
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http://dx.doi.org/10.1016/j.amjoto.2012.09.007 | DOI Listing |
Physiol Behav
December 2024
Instituto de Investigaciones Cerebrales, Universidad Veracruzana, Avenida Luis Castelazo s/n Col. Industrial Ánimas, Xalapa, Veracruz C. P. 91190. Mexico.
The pubertal phase involves significant brain reorganization, where external stressors and diet can profoundly influence long-term behavioral outcomes. In this study, we investigated the interaction between acute pubertal stress (via immune challenge) and a hypercaloric diet in adulthood on the copulatory sexual behavior of male Wistar rats. At postnatal day (PND) 35, pubertal males received a single injection of lipopolysaccharide (LPS, 1.
View Article and Find Full Text PDFEcotoxicol Environ Saf
December 2024
The Key Laboratory of Fertility Preservation and Maintenance of the Ministry of Education, Ningxia Medical University, Yinchuan, Ningxia 750004, China; School of Public Health, Ningxia Medical University, Yinchuan, Ningxia 750004, China; The Key Laboratory of Environmental Factors and Chronic Disease Control, Ningxia Medical University, Yinchuan, Ningxia 750004, China. Electronic address:
BP-3 is the most widely used ultraviolet absorber, but its toxic effects and mechanisms far from being elucidated. This study evaluated the male developmental reproductive toxicities and mechanism of low-doses of BP-3. The results indicated that BP-3 (2.
View Article and Find Full Text PDFAddict Biol
December 2024
Department of Psychological and Brain Sciences, University of California Santa Barbara, Santa Barbara, California, USA.
The early initiation of binge-drinking and biological sex are critical risk factors for the development of affective disturbances and cognitive decline, as well as neurodegenerative diseases including Alzheimer's disease. Further, a history of excessive alcohol consumption alters normal age-related changes in the pattern of protein expression in the brain, which may relate to an acceleration of cognitive decline. Here, we aimed to disentangle the interrelation between a history of binge-drinking during adolescence, biological sex and normal aging on the manifestation of negative affect, cognitive decline and associated biochemical pathology.
View Article and Find Full Text PDFNeuroscience
December 2024
Department of Anesthesiology, Sun Yat-Sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. Electronic address:
Postoperative neurocognitive disorder (PND) is a prevalent complication following surgery and anesthesia, characterized by progressive cognitive decline. The precise etiology of PND remains unknown, and effective targeted therapeutic strategies are lacking. Transcranial near-infrared light (tNIRL) has shown potential benefits for cognitive dysfunction diseases, but its effect on PND remains unclear.
View Article and Find Full Text PDFAnesth Analg
November 2024
From the Department of Anesthesia and Acute Pain Medicine, St Vincent's Hospital, Melbourne, Victoria, Australia.
Preoperative biofluid biomarkers reflecting pathophysiological, neuronal injury, and inflammation as well as those for Alzheimer's disease (AD) may be valuable tools for the risk stratification of perioperative neurocognitive disorders (PNDs) in older adults. We summarized current evidence relating these preoperative biomarkers to PND beyond 7 days, in older surgical participants aged ≥60 years. Studies that evaluated the association of preoperative biomarkers with cognitive decline as an outcome, beyond 7 days, were identified through searches of 6 databases and 3 trial registries to 17 January 2024.
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