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Fluconazole-induced Stevens-Johnson syndrome at Libreville University Hospital - Gabon: A case report.
Int J Risk Saf Med
March 2025
Pharmaco-epidemiology and Pharmacoeconomics Research Team, Pharmacology and Toxicology Laboratory, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco.
BackgroundStevens-Johnson syndrome (SJS), a rare and severe toxic epidermal necrolysis, is reported here for the first time at the University Hospital Center of Libreville (CHUL), suspected to be related to fluconazole administration.ObjectiveTo inform clinicians about the risks associated with fluconazole in immunocompromised patients and the related healthcare expenses.Case presentationThe patient is a 39-year-old immunocompromised woman who received a single dose 400 mg of fluconazole.
View Article and Find Full Text PDFRecommendations on how to proceed in case of suspected allergy to penicillin/β-lactam antibiotics: Position paper of the German Society for Allergology and Clinical Immunology (DGAKI) in cooperation with the German Society for Pediatric Allergology (GPA), Austrian Society for Allergology and Immunology (ÖGAI) and the Swiss Society for Allergology and Immunology (SGAI).
Allergol Select
March 2025
Allergology and Immunology, Department of Dermatology, Venereology and Allergology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
β-lactam antibiotics (BLAs) are still the antibiotics of first choice for the treatment of many bacterial infections. Treatment with a BLA is often hindered by a suspected allergy, up to 10% of the population report an allergy to penicillin. After allergological evaluation of the suspected allergic reaction to a BLA, most patients show a low probability of a BLA allergy; only in a minority of cases an allergic reaction to the repeated administration of a BLA appear likely in view of the previous history.
View Article and Find Full Text PDF, and -like MO-1 infection in the brain of a child with seizures, mycotoxin exposure and suspected Rasmussen's encephalitis.
J Cent Nerv Syst Dis
March 2025
From the Department of Clinical Sciences and the Intracellular Pathogens Research Laboratory, Comparative Medicine Institute, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.
Background: In conjunction with more sensitive culture and molecular diagnostic testing modalities, simultaneous or sequential infection with more than 1 vector borne zoonotic pathogen is being increasingly documented in human patients. On a frequent basis, many people are exposed to apparently healthy, but infected, domestic and wild animals, the arthropod vectors with which these animals have co-evolved, and the bacterial, protozoal and other pathogens for which various animals are reservoirs. Unsuspected zoonotic transmission by scratch, bite, or vector exposures can result in chronic, indolent, or potentially life-threatening infections.
View Article and Find Full Text PDFThe aim of this article is to extend the knowledge of an unusual presentation of oral syphilis. A 62-year-old man sought evaluation for a severely painful, deeply ulcerated lesion on the floor of the mouth. Two previous oral biopsies revealed nonspecific ulceration with inflammation.
View Article and Find Full Text PDFPosterior cervical instrumented fusion case complicated by acute generalized erythematous pustulosis.
J Surg Case Rep
March 2025
Department of Neurosurgery, Neurosurgery, The Walton Centre NHS Foundation Trust, Lower Lane, Liverpool L9 7LJ, United Kingdom.
This case report describes the first case of acute generalised erythematous pustulosis (AGEP) following cervical spinal surgery. A 74-year-old male post-operatively developed a painful, exudative bullous rash progressing from the posterior cervical wound site. Initial management with antibiotics for suspected cellulitis failed, leading to further investigation and a diagnosis of AGEP by dermatology.
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