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New insights on the role of CD8(+)CD57(+) T-cells in cancer. | LitMetric
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New insights on the role of CD8(+)CD57(+) T-cells in cancer.

Richard C Wu Patrick Hwu Laszlo G Radvanyi

Oncoimmunology

Department of Melanoma Medical Oncology; University of Texas M.D. Anderson Cancer Center; Houston, TX USA ; University of Texas Graduate School of Biomedical Sciences; Houston, TX USA ; University of Texas Medical School at Houston; Houston, TX USA.

Published: September 2012

Incomplete differentiation of CD8+ cytotoxic T-lymphocytes (CTLs) in the tumor microenvironment is associated with cancer progression. We describe a new type of tumor-infiltrating CD8+CD57+ T cell in cancer with hybrid phenotypic and functional properties of both an early effector-memory cell and a terminally-differentiated effector cell. These cells behave as incompletely-differentiated CTLs.

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 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489757PMC
http://dx.doi.org/10.4161/onci.20307DOI Listing

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