A diverse 23-compound library of N-1 substituted 2-aminobenzimidazoles was synthesized via an efficient three-step process. This small library produced several non-toxic biofilm modulators of two strains of MRSA. Preliminary mechanistic studies reveal a zinc-dependent mode of action for these compounds.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496259 | PMC |
| http://dx.doi.org/10.1039/C2MD20244A | DOI Listing |
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