Welcome to the guest zone: By combining hyperpolarized xenon and simple low-field NMR devices it is possible to obtain more control over hydrogels that show potential as drug delivery systems. An alternative way of polymer swelling-degree determination is demonstrated with real-time NMR analysis. An ideal region for solvent uptake can be defined in which the absorbed solvent molecules are completely confined in the nano-porous network of the hydrogel.
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| http://dx.doi.org/10.1002/cphc.201200658 | DOI Listing |
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Evaluation of an integrated variable flip angle protocol to estimate coil B for hyperpolarized MRI.
Magn Reson Med
November 2024
Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, UK.
Purpose: The purpose of this work is to validate a simple and versatile integrated variable flip angle (VFA) method for mapping B in hyperpolarized MRI, which can be used to correct signal variations due to coil inhomogeneity.
Theory And Methods: Simulations were run to assess performance of the VFA B mapping method compared to the currently used constant flip angle (CFA) approach. Simulation results were used to inform the design of VFA sequences, validated in four volunteers for hyperpolarized xenon-129 imaging of the lungs and another four volunteers for hyperpolarized carbon-13 imaging of the human brain.
Direct imaging of pulmonary gas exchange with hyperpolarized xenon MRI.
Innovation (Camb)
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State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan 430071, China.
Regional variations in hyperpolarized 129Xe lung MRI: Insights from CSI-CSSR and CSSR in healthy and irradiated rat models.
Magn Reson Med
March 2025
Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Purpose: To compare pulmonary function metrics obtained with hyperpolarized xenon-129 (HXe) MRS, using chemical shift saturation recovery (CSSR) and CSI-CSSR, in healthy rats and a rat model of radiation-induced lung injury.
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Department of Internal Medicine, University of Missouri, 1 Hospital Drive, Columbia, MO 65212, USA. Electronic address:
Hyperpolarized Xenon MRI (HPG MRI) has been studied for its potential use in assessing lung function in patients with cystic fibrosis (CF) and in patients with asthma. We present a case of a man with overlapping cystic fibrosis and allergic asthma with severe obstructive lung disease in which spirometry and computed topography (CT) imaging was unable to determine the primary cause for his uncontrolled symptoms. HPG MRI was used to guide a tissue biopsy and determine the primary driver to be allergic asthma.
View Article and Find Full Text PDFXe Image Processing Pipeline: An open-source, graphical user interface application for the analysis of hyperpolarized Xe MRI.
Magn Reson Med
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Center for Pulmonary Imaging Research, Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
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