Enamine catalysis in flow with an immobilized peptidic catalyst.

ChemSusChem

Laboratorium für Organische Chemie, ETH Zürich, Wolfgang-Pauli-Strasse 10, 8093 Zürich, Switzerland.

Published: February 2013

Pep talk: An immobilized peptidic catalyst achieves more than 600 turnovers in a continuous-flow system, allowing the production of chiral γ-nitroaldehydes with excellent stereoselectivities on a scale of >450 mmol (>100 g). Such a high efficiency opens the way for more practical applications of enamine catalysis.

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Source
http://dx.doi.org/10.1002/cssc.201200740DOI Listing

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