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Acute Effects of Serial and Integrated Concurrent Exercise on Circulating microRNAs -126 and -222 in Sedentary Adults.
Int J Exerc Sci
December 2024
School of Health Promotion and Kinesiology, Texas Woman's University, Denton, TX, USA.
The purpose of this study was to compare changes in circulating microRNAs -126 (c-miR-126) and -222 (c-miR-222) following acute serial concurrent exercise (SCE) and integrated concurrent exercise (ICE) sessions among young, sedentary adults. Ten males and 9 females completed the study procedures. For SCE, participants performed resistance exercise (RE) followed by aerobic exercise (AE), without mixing the two.
View Article and Find Full Text PDFSix months of chemotherapy using current agents is standard of care for pulmonary, drug-sensitive tuberculosis (TB), even though some are believed to be cured more rapidly and others require longer therapy. Understanding what factors determine the length of treatment required for durable cure in individual patients would allow individualization of treatment durations, provide better clinical tools to determine the of appropriate duration of new regimens, as well as reduce the cost of large Phase III studies to determine the optimal combinations to use in TB control programs. We conducted a randomized clinical trial in South Africa and China that recruited 704 participants with newly diagnosed, drug-sensitive pulmonary tuberculosis and stratified them based on radiographic disease characteristics as assessed by FDG PET/CT scan readers.
View Article and Find Full Text PDFChildren and providers' perspectives on once-weekly rifapentine and isoniazid TB preventive therapy.
IJTLD Open
January 2025
Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Background: TB preventive treatment (TPT) prevents the development of TB disease in individuals at risk of progression from infection to disease. However, implementation of TPT for children is poor in most high-burden settings. The long duration and pill burden of the 6-month once-daily isoniazid regimen (6H) pose significant barriers to completion.
View Article and Find Full Text PDFComparative pharmacokinetics study of two tablet formulations of delpazolid, a novel oxazolidinone class antibiotic.
Transl Clin Pharmacol
December 2024
Department of Clinical Pharmacology and Therapeutics, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam 13620, Korea.
Unlabelled: Delpazolid is an oxazolidinone-class antibiotic under development for treating diseases caused by antimicrobial-resistant gram-positive bacteria. This study compared the pharmacokinetics (PK) and safety of two formulations of delpazolid 400 mg with distinct excipient compositions: Batch No. 3183817R (test drug) and Batch No.
View Article and Find Full Text PDFAssociation of Pre- and Postinjury Mental Health With Long-term Clinical and Financial Outcomes.
J Trauma Acute Care Surg
January 2025
From the Department of Surgery (P.L.J., M.R.H., C.L.M., J.R.M., J.D.K., J.L.J.), University of Michigan Medical School; Center for Healthcare Outcomes and Policy (P.L.J., M.R.H., C.L.M., B.W.O., J.W.S.) and Department of Orthopedic Surgery (B.W.O.), University of Michigan Medical School; Department of Surgery (W.J.C.), Trinity Health Ann Arbor Hospital, Ann Arbor; Department of Surgery (B.D.M.), University of Michigan Health-Sparrow, Lansing; Department of Surgery (A.N.K.), Trinity Health Oakland Campus, Pontiac, Michigan; and Department of Surgery (J.W.S.), University of Washington, Harborview Medical Center, Seattle, Washington.
Background: As increased attention is placed on optimizing long-term outcomes of trauma patients by addressing mental health, little is known regarding the interplay of pre- and postinjury mental health on long-term financial and functional outcomes.
Methods: Patients from 19 Level 1 and 2 trauma centers took part in serial surveys 1 to 24 months postdischarge. Preinjury mental health diagnoses were identified using trauma registry data and postinjury mental health symptoms from survey data.
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