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Clinical Microbiome Analysis by Mass Spectrometry-Based Metaproteomics.
Annu Rev Anal Chem (Palo Alto Calif)
January 2025
2School of Pharmaceutical Sciences, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada; email:
Mass spectrometry-based proteomics and metaproteomics have long been used in the study of human microbiomes, with the potential of metaproteomics only recently being fully harnessed. This progress is due to the advancements of high-performance mass spectrometers, innovative proteomics strategies, and the development of dedicated bioinformatics tools. In this review, we critically examine the recent technological developments that enhance the application of metaproteomics in clinical microbiome analysis.
View Article and Find Full Text PDFImproving Hair Scar Defects Through the Integration of Autologous Fat Transplantation and Hair Follicle Unit Transplantation.
J Craniofac Surg
November 2024
Department of Plastic and Reconstructive Surgery, The Second Affiliated Hospital of Nanchang University.
Objective: To assess the clinical efficacy of combining autologous fat grafting with hair follicle unit transplantation.
Methods: The authors conducted a retrospective analysis involving 30 patients at the Department of Plastic Surgery, Second Affiliated Hospital of Nanchang University, between January 2021 and January 2023. Granular fat was harvested from the thigh's posterior aspect using liposuction.
Empathy is an aspect of social cognition which has gained much attention to explain sexual violence perpetration, with research resulting in mixed and contradictory findings. Another aspect of social cognition, which has been linked to, and even used synonymously with, cognitive empathy is Theory of Mind (ToM). However, research is severely lacking on the role which ToM may play in sexual violence.
View Article and Find Full Text PDFA distributed subcortical circuit linked to instrumental information-seeking about threat.
Proc Natl Acad Sci U S A
January 2025
Wellcome Centre for Integrative Neuroimaging, Department of Experimental Psychology, University of Oxford, Oxford OX1 3TA, United Kingdom.
Daily life for humans and other animals requires switching between periods of threat- and reward-oriented behavior. We investigated neural activity associated with spontaneous switching, in a naturalistic task, between foraging for rewards and seeking information about potential threats with 7T fMRI in healthy humans. Switching was driven by estimates of likelihood of threat and reward.
View Article and Find Full Text PDFVesalius and His Manikin: An Enduring Influence on Modern Anatomic Teaching.
Neurosurgery
February 2025
The Loyal and Edith Davis Neurosurgical Research Laboratory, Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix , Arizona , USA.
Anatomic teaching has long informed surgical knowledge, experience, and skills. One tool for teaching that emerged during the Renaissance was the fugitive anatomic sheet, which used flap layers to reveal different levels of anatomy. In 1538, Vogtherr introduced the first fugitive sheets, which included illustrations of male and female figures with a torso paper flap that, when lifted, revealed the internal organs in a cartoonish style.
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