AI Article Synopsis
- Researchers studied the impact of Ang2-siRNA on malignant melanoma growth by examining Ang2 expression levels in cancer cells, both in the lab and in live subjects.
- They created a lentivirus carrying Ang2-siRNA and used it to develop a mouse model with transplanted malignant melanoma.
- The results showed that Ang2-siRNA reduced Ang2 mRNA levels and slowed tumor growth, suggesting potential for gene therapy in treating malignant melanoma.
Article Abstract
To investigate the intervention therapy effect on the growth of malignant melanoma, we have made an observation of expression levels of Ang2 in malignant melanoma cells, which was transduced by small interfering RNA (Ang2-siRNA) of Ang2 in vitro and in vivo. We successfully constructed Ang2-siRNA lent virus, and constructed nude mice model by transplanting malignant melanoma. Ang2-siRNA lent virus inhibited Ang2 mRNA of malignant melanoma in vitro and in vivo, and inhibited malignant melanoma tumor growth at the same time. Ang2-siRNA lent virus can interfere expression levels of Ang2 in malignant melanoma cells, inhibit tumor growth, and silent Ang2 gene expression, which may pave a new way for clinical gene therapy of malignant melanoma.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538013 | PMC |
| http://dx.doi.org/10.1007/s11033-012-2189-4 | DOI Listing |
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