AI Article Synopsis
- The study aims to determine if patients with a history of kidney stones (stone formers) reflect the condition of those who currently have stones (stone carriers).
- Researchers analyzed 463 gout patients, finding that while 34% had current kidney stones detected via CT, only 16% had a previous history of stones, indicating many with stones had no prior history.
- The findings suggest that relying solely on past urolithiasis history may underestimate the number of patients with kidney stones, and that greater stone burden correlates with more significant kidney health issues, making stone carriers a better focus for understanding gout-related kidney stone formation.
Article Abstract
Purpose: We clarified whether the clinical profiles of patients with a history of urolithiasis (stone formers) truly reflect those of patients who currently have renal stones (stone carriers).
Materials And Methods: We evaluated 463 patients with gout using helical computerized tomography, urolithiasis history and relevant clinical parameters.
Results: Nephrolithiasis was observed in 157 of the 463 patients (34%) on helical computerized tomography but only 75 (16%) had a urolithiasis history. Of the 157 stone carriers 107 (68%) did not have a urolithiasis history. In those 157 patients serum urate and serum creatinine were higher than in the 306 nonstone carriers (p = 0.017), and the estimated glomerular filtration rate and urinary pH were lower (p = 0.0096 and 0.0249, respectively). However, there was no significant difference in laboratory findings between the 75 stone formers and 388 nonstone formers. Serum urate and creatinine were higher, and the estimated glomerular filtration rate and urine pH in bilateral stone carriers were lower than in unilateral stone carriers. According to HU density attenuation values on computerized tomography, an estimated third of the calculi that complicated 31 recent gout cases was uric acid.
Conclusions: The concept of stone formers may lead to underestimating the prevalence of urolithiasis. Our analysis of stone carriers showed that a higher stone burden is associated with greater renal derangement, as determined by serum urate and creatinine, the estimated glomerular filtration rate and urine pH. To accurately clarify the correlation of gout and urolithiasis, it is advantageous to select stone carriers as subjects of study.
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| http://dx.doi.org/10.1016/j.juro.2012.11.076 | DOI Listing |
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