AI Article Synopsis
- The origin of M cells, whether from a separate cell lineage or through changes in existing cells, remains a topic of discussion.
- A study by Tahoun et al. (2012) reveals that SopB, a virulence factor from Salmonella enterica serovar Typhimurium, plays a role in transforming regular intestinal cells (enterocytes) into M cells.
- This finding sheds light on how pathogens can manipulate host cell types to enhance their infection capabilities.
Article Abstract
Whether M cells arise from a distinct lineage or result from phenotypic transition is a matter of debate. In this issue of Cell Host & Microbe, Tahoun et al. (2012) provide evidence that SopB, a virulence factor of Salmonella enterica serovar Typhimurium, can induce phenotypic transition of lymphoid follicle-associated enterocytes into M cells.
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| http://dx.doi.org/10.1016/j.chom.2012.11.003 | DOI Listing |
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