Background: Different suspension systems that are used within prosthetic devices may alter the distribution of pressure inside the prosthetic socket in lower limb amputees. This study aimed to compare the interface pressure of a new magnetic suspension system with the pin/lock and Seal-In suspension systems.

Methods: Twelve unilateral transtibial amputees participated in the study. The subjects walked on a level walkway at a self-selected speed. The resultant peak pressure with the three different suspension systems was recorded using F-socket transducers.

Findings: There were significant statistical differences between the three studied suspension systems. Pair-wise analyses revealed that the mean peak pressure (kPa) was lower with the magnetic system than it was with the pin/lock system over the anterior and posterior aspects during one gait cycle (89.89 vs. 79.26 and 47.22 vs. 26.01, respectively). Overall, the average peak pressure values were higher with the Seal-In system than they were with the new magnetic lock and pin/lock system.

Interpretation: The new magnetic system might reduce the pressure within the prosthetic socket in comparison to the pin/lock and Seal-In system during one gait cycle. This is particularly important during the swing phase of gait and may reduce the pain and discomfort at the distal residual limb in comparison to the pin/lock system.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clinbiomech.2012.10.002DOI Listing

Publication Analysis

Top Keywords

suspension systems
12
peak pressure
12
interface pressure
8
system
8
suspension system
8
lower limb
8
limb amputees
8
prosthetic socket
8
system pin/lock
8
pin/lock seal-in
8

Similar Publications

Road surface roughness is the cause of vehicle vibration, which is considered a system disturbance. Previous studies on suspension system control often ignore the influence of disturbances while designing the controller, leading to system performance degradation under severe vibration conditions. In this work, we propose a control method to improve active suspension performance that reduces vehicle vibration by eliminating the influence of road disturbances.

View Article and Find Full Text PDF

Gamma-Retroviral (RVVs) and lentiviral vectors (LVVs) represent indispensable tools in somatic gene therapy, mediating the efficient, stable transfer of therapeutic genes into a variety of human target cells. LVVs, in contrast to RVVs, are capable of stably genetically modifying non-proliferating target cells, making them the superior instrument in cell and gene therapy. To date, the LVV manufacturing process employs human embryonic kidney cells (HEK293) and derivatives thereof transiently transfected with multiple plasmids encoding the required viral vector components.

View Article and Find Full Text PDF

Different approaches are being developed to efficiently produce in vitro platelets from cultured megakaryocytes to meet the constant demand of platelet transfusion and serve for research purposes. Recent works have shown that turbulence and periodic stress can significantly enhance platelet yield. Here we have developed and characterized a platelet production device that takes in account these properties.

View Article and Find Full Text PDF

Introduction: Rhein, a natural bioactive lipophilic compound with numerous pharmacological activities, faces limitations in clinical application due to poor aqueous solubility and low bioavailability. Thus, this study aimed to develop a rhein-loaded self-nano emulsifying drug delivery system (RL-SNEDDS) to improve solubility and bioavailability.

Methods: The RL-SNEDDS was prepared by aqueous titration method with eucalyptus oil (oil phase), tween 80 (surfactant), and PEG 400 (co-surfactant) and optimization was performed by 3 factorial design.

View Article and Find Full Text PDF

Reversible light-responsive protein hydrogel for on-demand cell encapsulation and release.

Acta Biomater

January 2025

Division of Chemical Biology and Medicinal Chemistry, College of Pharmacy, University of Texas at Austin, Austin, TX, 78712, USA. Electronic address:

The design of biomaterials that can reconfigure on-demand in response to external stimuli is an emerging area in materials research. However, achieving reversible assembly of protein-based biomaterials by light input remains a major challenge. Here, we present the engineering of a new protein material that is capable of switching between liquid and solid state reversibly, controlled by lights of different wavelengths.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!