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Raman spectroscopy for monitoring free sulfhydryl formation during monoclonal antibody manufacturing.
J Pharm Biomed Anal
January 2025
Biologics' Process Research & Development (BPR&D), MRL, Merck & Co., Inc., Rahway, NJ, USA.
During production, harvested cell culture fluid (HCCF) can degrade due to reductases breaking interchain disulfide bonds, forming low molecular weight (LMW) impurities that contain free sulfhydryl and high molecular weight (HMW) impurities through disulfide shuffling. Thus, detecting and quantifying the free sulfhydryl increase in HCCF is critical. Herein, Raman spectroscopy is implemented as a process analytical technology, and multivariate data analysis is applied to characterize and quantify sulfhydryl formation in HCCF with disulfide-containing indicator molecules.
View Article and Find Full Text PDFLinking social capital and the political economy of substance treatment delivery: The case of recovery-oriented systems of care in Illinois.
Int J Drug Policy
October 2024
School of Public Health and Social Justice, Saint Louis University, St. Louis, USA.
Background: Recovery-oriented systems of care have been a widely supported approach to transforming existing substance treatment programs across different states through developing recovery programs and interagency networks. However, little is known about the facilitators and barriers influencing their development and implementation.
Methods: Qualitative study of 5 different recovery-oriented systems of care in Illinois.
Diversified Synthesis of -Benzoyl Piperidine Tetraoxane Analogues Using Molybdenum Trioxide as a Newer Catalyst and Its Antiplasmodial Activity.
ACS Omega
July 2024
Chemical Biology Laboratory, Department of Chemistry, University of Delhi, Delhi 110007, India.
Molybdenum trioxide has been proven to be an efficient catalyst in synthesizing mixed -benzoyl piperidine dispiro-1,2,4,5-tetraoxane analogues using a one-pot reaction. This catalyst facilitated the synthesis of 21 tetraoxanes using cyclic, acyclic, and aromatic ketones. The structure and methodology of this reaction have been validated by single-crystal X-ray analysis of compound ″3g″.
View Article and Find Full Text PDFCatalytic battle of activated carbon supported transition metal atom towards adsorption and dissociation of molecular hydrogen: Progress towards quantum chemical application on renewable energy resource.
J Mol Graph Model
September 2024
Department of Chemistry, Assam University, Silchar, 788011, Assam, India. Electronic address:
Article Synopsis
- DFT analysis shows that hydrogen molecules are effectively adsorbed and dissociated on transition metal-doped activated carbon (AC), enhancing hydrogen storage capabilities.
- Transition metals preferentially occupy the five-membered rings of AC, which become more deformed compared to six-membered rings upon doping, indicating structural changes that impact catalyst performance.
- Among the metals studied, Ru, Rh, Os, and Ir doped ACs demonstrate superior hydrogen dissociation efficiency, while Cu doped AC is the least effective, supported by evaluations of bond lengths, vibrational analysis, and Gibbs free energy changes.
Two babies, two bonds: Frequency and correlates of differential maternal-infant bonding in mothers of twins.
Infant Ment Health J
May 2024
Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
We assessed prevalence and correlates of differential maternal-infant bonding (i.e., experiencing a stronger bond with one baby vs.
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