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Dispersal promotes stability and persistence of exploited yeast mutualisms.
ISME J
January 2025
Biology Department, University of Massachusetts Boston, Boston, MA 02125.
Multi-species mutualistic interactions are ubiquitous and essential in nature, yet they face several threats, many of which have been exacerbated in the Anthropocene era. Understanding the factors that drive the stability and persistence of mutualism has become increasingly important in light of global change. Although dispersal is widely recognized as a crucial spatially explicit process in maintaining biodiversity and community structure, knowledge about how the dispersal of mutualists contributes to the persistence of mutualistic systems remains limited.
View Article and Find Full Text PDFBrain signaling becomes less integrated and more segregated with age.
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December 2024
Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, NY, USA.
The integration-segregation framework is a popular first step to understand brain dynamics because it simplifies brain dynamics into two states based on global versus local signaling patterns. However, there is no consensus for how to best define the two states. Here, we map integration and segregation to order and disorder states from the Ising model in physics to calculate state probabilities, and , from functional MRI data.
View Article and Find Full Text PDFConscientious objection: a global health perspective.
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Global Bioethics Collaborative, Los Angeles, California, USA.
Conscientious objection is a critical topic that has been sparsely discussed from a global health perspective, despite its special relevance to our inherently diverse field. In this Analysis paper, we argue that blanket prohibitions of a specific type of non-discriminatory conscientious objection are unjustified in the global health context. We begin both by introducing a nuanced account of conscience that is grounded in moral psychology and by providing an overview of discriminatory and non-discriminatory forms of objection.
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Medical Officer, District Hospital, Ambedkar Nagar, Uttar Pradesh, India.
Background: Over 450 million individuals worldwide suffer from mental illnesses, according to epidemiological data, making this one of the biggest problems facing modern medicine. People often react in a fairly discriminatory way to those with mental illness, and stigmatizing views toward those with mental illness are ubiquitous. In India, people who suffer from mental illness live with their families, and the stigma associated with mental illness has a significant impact on how effectively these people are treated over time by their families and communities.
View Article and Find Full Text PDF[Current advances in the analysis of free RNA modified nucleosides by high performance liquid chromatography-tandem mass spectrometry].
Se Pu
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State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China;3. University of Chinese Academy of Sciences, Beijing 100049, China.
Post-transcriptional ribonucleic acid (RNA) modifications play crucial roles in regulating gene expression, with both eukaryotic and prokaryotic RNA exhibiting more than 170 distinct and ubiquitous modifications. RNA turnover generates numerous free nucleosides, including unmodified nucleosides and a variety of modified ones. Unlike unmodified nucleosides, modified nucleosides are not further degraded or used in the salvage-synthesis pathway owing to a lack of specific enzymes, which leads to the cytosolic accumulation or cellular efflux of modified nucleosides.
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