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Re-evaluating evidence for giant genomes in amoebae.
Genet Mol Biol
December 2024
Universidade de São Paulo, Instituto de Biociências, Departamento de Zoologia, São Paulo, SP, Brazil.
Here we reassess available evidence for the long-held misconception of amoebae possessing exceptionally large genomes. Traditionally, estimates relied on inaccurate methods like DNA weight measurements, leading to inflated sizes. These methods failed to account for contaminating DNA from prey, endosymbionts, and intrinsic genomic features like ribosomal operon amplification.
View Article and Find Full Text PDFNovel High-Quality Amoeba Genomes Reveal Widespread Codon Usage Mismatch Between Giant Viruses and Their Hosts.
Genome Biol Evol
January 2025
Centre for Microbiology and Environmental Systems Science, Division of Microbial Ecology, University of Vienna, Vienna 1030, Austria.
The need for high-quality protist genomes has prevented in-depth computational and experimental studies of giant virus-host interactions. In addition, our current knowledge of host range is highly biased due to the few hosts used to isolate novel giant viruses. This study presents 6 high-quality amoeba genomes from known and potential giant virus hosts belonging to 2 distinct eukaryotic clades: Amoebozoa and Discoba.
View Article and Find Full Text PDFRevisiting the concept of giant viruses.
Microbes Infect
December 2024
Laboratório de Vírus, Departamento de Microbiologia, Universidade Federal de Minas Gerais (UFMG). Belo Horizonte, Minas Gerais, 31270-901, Brazil. Electronic address:
Giant viruses have fascinated the scientific community due to their immense particles and extensive genomes. A significant surge of interest in the field has been observed over the past 20 years following the discovery of mimiviruses, the first amoeba-infecting viruses described. However, with the discovery of new amoeba viruses and those from other protists, the concept of "giant viruses" has become increasingly controversial in the scientific literature.
View Article and Find Full Text PDFCytochromes b5 Occurrence in Viruses Belonging to the Order Megavirales.
Res Sq
October 2024
Biology Department, Woods Hole Oceanographic Institution, Woods Hole, Massachusetts 02543, USA.
Cytochrome b5 is a small electron transport protein that is found in animals, plants, fungi and photosynthetic proteobacteria where it plays key metabolic roles in energy production, lipid and sterol biosynthesis and cytochrome P450 biochemistry. Previously it was shown that a gene encoding a soluble and functional cytochrome b5 protein was encoded in the large double stranded DNA virus OtV2 that infects the unicellular marine green alga , the smallest free-living eukaryote described to-date. This single gene represented a unique finding in the virosphere.
View Article and Find Full Text PDFAcanthamoeba polyphaga de novo transcriptome and its dynamics during Mimivirus infection.
Sci Rep
October 2024
Department of Biomolecular Sciences, Weizmann Institute of Science, 7610001, Rehovot, Israel.
Article Synopsis
- Mimivirus bradfordmassiliense is a giant virus that infects Acanthamoeba species, leading to significant changes in the host's gene expression during infection.
- Long- and short-read sequencing techniques revealed a complex transcriptome of the host, showing a total of 22,604 transcripts and major downregulation in genes involved in crucial cellular functions like cytoskeleton stability and DNA synthesis, indicating cell cycle arrest.
- The virus itself exhibited dynamic gene expression trends, with early stages focusing on DNA-related processes and later stages emphasizing lipid metabolism and protease activity, suggesting extensive disruption of the host's cellular organization.
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