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FOXR2 Targets LHX6+/DLX+ Neural Lineages to Drive Central Nervous System Neuroblastoma.
Cancer Res
January 2025
Lady Davis Research Institute, Jewish General Hospital, Montreal, Canada.
Central nervous system neuroblastoma with forkhead box R2 (FOXR2) activation (NB-FOXR2) is a high-grade tumor of the brain hemispheres and a newly identified molecular entity. Tumors express dual neuronal and glial markers, leading to frequent misdiagnoses, and limited information exists on the role of FOXR2 in their genesis. To identify their cellular origins, we profiled the transcriptomes of NB-FOXR2 tumors at the bulk and single-cell levels and integrated these profiles with large single-cell references of the normal brain.
View Article and Find Full Text PDFThe first review on prenatal drug exposure and ocular malformation occurrence.
Front Pediatr
September 2024
Department of Medical and Clinical Pharmacology, University Hospital Center, CERPOP INSERM UMR 1295 - SPHERE Team, Toulouse, France.
Even though a non-negligible portion of congenital eye anomalies has a clear genetic origin, an etiology is not found for most patients. Prenatal medication exposure is recognized to be involved in fetal malformations and several medications are specifically known to alter eye morphogenesis during embryonic development leading to congenital eye defects. We explored and reviewed the role of medications described in the genesis of ocular malformations, a role that has been little evaluated and probably still underestimated especially since several studies have shown the wide exposure of pregnant women to medication.
View Article and Find Full Text PDFSafety and efficacy of intralesional bleomycin for keloids and hypertrophic scars: A systematic review and meta-analysis.
J Cosmet Dermatol
November 2024
Plastic and Reconstructive Surgery & Burns, Affiliated Hospital of North Sichuan Medical College, Sichuan, Nanchong, China.
Article Synopsis
- Bleomycin, initially an antitumor drug, was researched for treating hypertrophic scars and keloids, with mixed results regarding efficacy and safety among individuals.
- A review of various studies revealed that topical bleomycin was more effective in scar reduction compared to triamcinolone, but showed no significant differences in pigmentation and recurrence rates versus other treatments.
- While bleomycin led to less skin atrophy and telangiectasia, it was associated with increased pain; further studies are needed for a thorough evaluation of its safety and effectiveness.
Perinatal Predictors and Mediators of Attachment Patterns in Preschool Children: Exploration of Children's Contributions in Interactions with Mothers.
Children (Basel)
August 2024
Owerko Centre, Alberta Children's Hospital Research Institute, Calgary, AB T2N 1N4, Canada.
Insecure and disorganized attachment patterns in children are linked to poor health outcomes over the lifespan. Attachment patterns may be predicted by variables that influence the quality of children's interactions with their primary caregivers/parents (usually mothers) such as prenatal and postnatal exposures and the children's own behaviours in interactions. The purposes of this exploratory study were to examine: (1) prenatal predictors of children's attachment patterns, and (2) postnatal mediators and moderators of associations between prenatal predictors and children's attachment patterns, with adjustment for relevant covariates.
View Article and Find Full Text PDFDevelopmental functions of microglia: Impact of psychosocial and physiological early life stress.
Neuropharmacology
November 2024
Department of Psychology, Ohio State University, Columbus, OH, USA; Department of Neuroscience, Ohio State University, Columbus, OH, USA; Institute for Behavioral Medicine Research, Ohio State University, Columbus, OH, USA; Chronic Brain Injury Program, Ohio State University, Columbus, OH, USA.
Microglia play numerous important roles in brain development. From early embryonic stages through adolescence, these immune cells influence neuronal genesis and maturation, guide connectivity, and shape brain circuits. They also interact with other glial cells and structures, influencing the brain's supportive microenvironment.
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