Context: Free fatty acids (FFAs) and triglycerides (TGs) are altered postburn, but whether these alterations are associated with postburn outcomes is not clear.
Objective: The aim of the present study was to analyze lipid metabolic profiles in pediatric burn patients and to correlate these profiles with patient outcomes and hospital courses.
Design And Setting: We conducted a prospective cohort study at an academic pediatric hospital burn center.
Patients: Our study included 219 pediatric burn patients.
Main Outcome Measures: Patients were stratified according to their plasma TG and FFA levels. Main patient outcomes, such as postburn morbidity and mortality, and clinical metabolic markers were analyzed.
Results: All groups were similar in demographics and injury characteristics. Patients with elevated TGs had significantly worse clinical outcomes associated with increased acute-phase protein synthesis indicating augmented inflammation and hypermetabolism, whereas increased FFAs did not seem to profoundly alter postburn outcomes.
Conclusions: Elevated TGs, but not FFAs, postburn are associated with worsened organ function and clinical outcomes.
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| http://dx.doi.org/10.1210/jc.2012-2599 | DOI Listing |
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