AI Article Synopsis
- The study focuses on the separation of 3-hydroxy-3-phenylisoindolin-1-ones using a method called dynamic preferential crystallization.
- These compounds can be racemized by undergoing ring-opening and ring-closing reactions with achiral intermediates in basic conditions.
- By crystallizing from a toluene solution with DBU and using stirring and solvent evaporation, the researchers successfully produced optically active crystals with high enantiomeric excess (ee) values.
Article Abstract
Separated: 3-hydroxy-3-phenylisoindolin-1-ones have been resolved by dynamic preferential crystallization. The compounds were effectively racemized through ring-opening and ring-closing reactions via achiral intermediates under basic conditions. Crystallization from a toluene solution containing 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) with stirring and evaporation of the solvent gave optically active crystals quantitatively with high ee values.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/anie.201205097 | DOI Listing |
Publication Analysis
Top Keywords
total spontaneous
4
spontaneous resolution
4
resolution deracemization
4
deracemization isoindolinones
4
isoindolinones separated
4
separated 3-hydroxy-3-phenylisoindolin-1-ones
4
3-hydroxy-3-phenylisoindolin-1-ones resolved
4
resolved dynamic
4
dynamic preferential
4
preferential crystallization
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!