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Plexin-B2 Mediates Orthodontic Tension-Induced Osteogenesis via the RhoA/F-Actin/YAP Pathway.
J Periodontal Res
November 2024
State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Aims: This study aims to investigate the role of Plexin-B2 in tension-induced osteogenesis of periodontal ligament stem cells (PDLSCs) and its biomechanical mechanism.
Methods: In vitro, cyclic tension simulated orthodontic forces to assess Plexin-B2 expression in PDLSCs. We then knocked out Plexin-B2 using lentivirus to explore its role in tension-induced osteogenesis.
KDF1 promotes ameloblast differentiation by inhibiting the IKK/IκB/NF-κB axis.
J Cell Physiol
December 2024
Department of Prosthodontics, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, China.
Enamel protects teeth from external irritation and its formation involves sequential differentiation of ameloblasts, a dental epithelial cell. Keratinocyte differentiation factor 1 (KDF1) is important in the development of epithelial tissues and organs. However, the specific role of KDF1 in enamel formation and corresponding regulatory mechanisms are unclear.
View Article and Find Full Text PDFSuccessful Replantation of an Anterior Tooth in an 11-Year-Old Child: A Case Report.
Cureus
July 2024
Pediatric and Preventive Dentistry, Sharad Pawar Dental College and Hospital, Datta Meghe Institute of Higher Education and Research (Deemed to be University), Wardha, IND.
Avulsion occurs when the tooth is completely knocked out of its alveolar socket. The maxillary central incisors are more vulnerable to avulsion due to their prominent position in the dental arch. This case report describes a successful permanent maxillary incisor replantation in an 11-year-old child.
View Article and Find Full Text PDFEfficient Production of 9,22-Dihydroxy-23,24-bisnorchol-4-ene-3-one from Phytosterols by Modifying Multiple Genes in .
Int J Mol Sci
March 2024
Laboratory of Biorefinery, Shanghai Advanced Research Institute, Chinese Academy of Sciences, No. 99 Haike Road, Pudong, Shanghai 201210, China.
Article Synopsis
- The study focused on improving the production of a steroid derivative, 9-OHBA, using a mutant strain (MFKD) from ATCC 35855, targeting the C22 metabolic pathway.
- The mutant strain MFKDΔ achieved an 81.47% accumulation of 9-OHBA, and a double mutant MFKDΔΔ further improved selectivity to 95.13%, resulting in an impressive yield of 6.81 g/L from phytosterols, outperforming previous strains.
Awareness about emergency management of avulsed tooth among intern dentists-a cross-sectional observational study.
J Clin Pediatr Dent
March 2024
Department of Oral and Maxillofacial Surgery & Diagnostic Sciences, College of Dentistry, Jouf University, 72311 Sakaka, Kingdom of Saudi Arabia.
Tooth avulsion is a frequently encountered dental emergency. Children are commonly reported group due to frequent sports activities, trauma, accidents and falls. Prompt emergency management is vital for long term success and to avoid morbidity.
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