AI Article Synopsis
- The study examined the anxiolytic effects of topiramate and diazepam on Wistar rats during different phases of the estrous cycle.
- Both drugs showed increased responses in anxiety-like behaviors during the proestrus phase at lower doses, while higher doses were necessary during metestrus-diestrus for effects to be seen.
- The findings indicate that the effectiveness of these treatments can be influenced by the estrous cycle phase, suggesting a potential link between hormonal changes and anxiety modulation.
Article Abstract
The anxiolytic-like effects of topiramate were assessed during several estrous cycle phases in Wistar rats tested in two animal models of anxiety-like behavior. In a conflict operant test, during proestrus, diazepam (1.3, 2.0mg/kg; P<0.05) or topiramate (20.0, 30.0mg/kg; P<0.05) increased the number of immediately punished responses. During metestrus-diestrus only the highest doses of diazepam (2.0mg/kg, P<0.05) or topiramate (30.0mg/kg, P<0.05) increased the number of immediately punished reinforcers. Similar results were obtained in the elevated plus-maze test: during proestrus, diazepam (1.3, 2.0mg/kg; P<0.05) or topiramate (20.0, 30.0mg/kg; P<0.05) produced anxiolytic-like actions. During metestrus-diestrus only the highest doses of diazepam (2.0mg/kg, P<0.05) or topiramate (30.0mg/kg, P<0.05) produced anxiolytic-like actions. Neither diazepam nor topiramate nor estrous cycle phases significantly modified the number of closed arm entries in the elevated plus-maze test. It is concluded that the response to neuromodulatory drugs for anxiety-like behavior varied according to the estrous cycle phases.
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| http://dx.doi.org/10.1016/j.pbb.2012.11.002 | DOI Listing |
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