Objective: To assess the nutritional status and prevalence of obesity among children with Down syndrome (DS).
Methods: The study group comprised pre-pubertal children, with clinically and cytogenetically proven DS. Healthy siblings, closest in age to the DS children, were used as a control group. Body weight, height, body mass index (BMI), triceps skinfold thickness (TSFT), and macro- and micronutrient intakes were measured in both groups. The study was conducted in Riyadh, Kingdom of Saudi Arabia, between February and May 2011.
Results: Children with DS were shorter than their siblings, but had comparable weights. The DS children had higher BMIs and higher TSFTs, compared with their siblings. The prevalence of overweight and obesity differed significantly between the DS and control groups. The DS children had significantly lower intakes of fat, protein, retinol, riboflavin, and potassium compared with their siblings.
Conclusion: Obesity appears to be a prominent feature among Saudi DS children.
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J Eval Clin Pract
February 2025
Centre for Health Care Management, Faculty of Management, University of Warsaw, Warsaw, Poland.
Intro: The article tests the hypothesis that we can draw practical knowledge from the experience of service providers operating in the past. The research questions were formulated: can the historical example of the organization of medical care in the Polish Children's Hospital named after Karol and Maria be used as a viable example today? Is it relevant for contemporary practitioners? And do we still use the knowledge of predecessors? The authors decided to use the interwar Hospital and an operating paediatric ward of the Child-Friendly Hospital for a comparative analysis.
Methods: The model of the European Regional Office of the World Health Organization for integrated delivery of health services was adopted as the analysis framework.
Am J Case Rep
December 2024
Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden.
BACKGROUND Limb-girdle muscular dystrophy recessive 1 (LGMDR1) is an autosomal recessive degenerative muscle disorder characterized by progressive muscular weakness caused by pathogenic variants in the CAPN3 gene. Desmoplastic small round cell tumors (DSRCT) are ultra-rare and aggressive soft tissue sarcomas usually in the abdominal cavity, molecularly characterized by the presence of a EWSR1::WT1 fusion transcript. Mouse models of muscular dystrophy, including LGMDR1, present an increased risk of soft tissue sarcomas.
View Article and Find Full Text PDFIran Biomed J
December 2024
Student Research and Technology Committee, Shirvan College of Nursing, North Khorasan University of Medical Sciences, Bojnord, Iran.
Purpose: To examine associations between clinical measures (self-reported and clinician-administered) and subsequent injury rates in the year after concussion return to play (RTP) among adolescent athletes.
Methods: We performed a prospective, longitudinal study of adolescents ages 13-18 years. Each participant was initially assessed within 21 days of concussion and again within 5 days of receiving RTP clearance from their physician.
Biochem Genet
December 2024
College of Medical Laboratory, Dalian Medical University, Dalian, 116044, People's Republic of China.
This study aims to establish a genetic risk assessment model based on a score of short tandem repeats (STRs) of polygenic inheritance. A total of 396 children and their biological parents were collected for STR genotyping. The numbers of tandem repeats of two alleles in one STR locus were assumed to be a quantitative genetic strength for disease incidence.
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