First-year renal allograft survival has increased, but whether this is associated with improvement in the long term is controversial. We analyzed 1045 consecutive adult deceased donor kidney transplant recipients from 1986 to 2001, with a follow-up to 2011. The aim of this study was to compare the graft half-life and attrition rates stratified by year of transplant in patients who received the graft in the periods 1986 to 1995 versus 1996 to 2001. The graft half-life increased significantly in the second period (P = .000) and the rate of graft loss stratified per year of evolution fell in all the study periods (P = .0000). In addition, the study period 1996 to 2001 was significantly associated with a reduction in graft failure risk compared with 1986 to 1995 in the multivariate analysis (P = .005). In conclusion, both short- and long-term graft survival increased significantly at our center.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.transproceed.2012.09.101DOI Listing

Publication Analysis

Top Keywords

long-term graft
8
graft loss
8
survival increased
8
graft half-life
8
stratified year
8
1986 1995
8
1996 2001
8
graft
7
rate long-term
4
loss fallen
4

Similar Publications

The maturation state and density of human cartilage microtissues influence their fusion and development into scaled-up grafts.

Acta Biomater

January 2025

Trinity Centre for Biomedical Engineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland; Department of Mechanical, Manufacturing and Biomedical Engineering, School of Engineering, Trinity College Dublin, Dublin, Ireland; Department of Anatomy and Regenerative Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland; Advanced Materials and Bioengineering Research Centre (AMBER), Royal College of Surgeons in Ireland and Trinity College Dublin, Dublin, Ireland. Electronic address:

Functional cartilaginous tissues can potentially be engineered by bringing together numerous microtissues (µTs) and allowing them to fuse and re-organize into larger, structurally organized grafts. The maturation level of individual microtissues is known to influence their capacity to fuse, however its impact on the long-term development of the resulting tissue remains unclear. The first objective of this study was to investigate the influence of the maturation state of human bone-marrow mesenchymal stem/stromal cells (hBM-MSCSs) derived microtissues on their fusion capacity and the phenotype of the final engineered tissue.

View Article and Find Full Text PDF

Predicting Time to First Rejection Episode in Lung Transplant Patients Using a Comprehensive Multi-Indicator Model.

J Inflamm Res

January 2025

Department of Clinical Laboratory, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, 510140, People's Republic of China.

Background: Rejection hinders long-term survival in lung transplantation, and no widely accepted biomarkers exist to predict rejection risk. This study aimed to develop and validate a prognostic model using laboratory data to predict the time to first rejection episode in lung transplant recipients.

Methods: Data from 160 lung transplant recipients were retrospectively collected.

View Article and Find Full Text PDF

Rhinoplasty Septal Cartilage Harvest and Reconstruction: The 4 Clicks.

Plast Reconstr Surg Glob Open

January 2025

From the Division of Plastic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX.

Successful rhinoplasty relies on a deep understanding of nasal anatomy and precise nasal tip control for lasting functional and aesthetic outcomes. Structural grafts, like septal extension grafts, are instrumental in maintaining tip position and projection with minimal long-term changes. This article details a systematic technique to harvest septal cartilage that maximizes graft material and allows for effective septal deviation correction.

View Article and Find Full Text PDF

Background And Objective: As the global population ages, degenerative spinal disorders are on the rise, leading to an increased focus on optimizing spinal fusion therapies. Despite the high success rate of iliac crest bone autografts, their usage is hampered by donor site morbidity and limited supply. The objective of this review is to assess the viability of ceramic-based synthetic materials as alternatives in spinal fusion surgeries.

View Article and Find Full Text PDF

Revisiting the unobtrusive role of exogenous stem cells beyond neural circuits replacement in spinal cord injury repair.

Theranostics

January 2025

Department of biochemistry and molecular biology, College of Life Sciences, Central South University, Changsha, 410078, Hunan, China.

Stem cell transplantation is a promising strategy to establish neural relays in situ for spinal cord injury (SCI) repair. Recent research has reported short-term survival of exogenous cells, irrespective of immunosuppressive drugs (ISD), results in similar function recovery, though the mechanisms remain unclear. This study aims to validate this short-term repair effect and the potential mechanisms in large animals.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!