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Catalase: A Potential Pharmacologic Target for Hydrogen Peroxide in the Treatment of COVID-19.
Curr Top Med Chem
October 2024
Department of Neuropharmacology, Institute of Experimental Medicine, Saint Petersburg, Russia.
Background: Acute respiratory distress syndrome in the elderly with COVID-19 complicated by airway obstruction with sputum and mucus, and cases of asphyxia with blood, serous fluid, pus, or meconium in newborns and people of different ages can sometimes cause hypoxemia and death from hypoxic damage to brain cells, because the medical standard does not include intrapulmonary injections of oxygen-producing solutions. The physical-chemical repurposing of hydrogen peroxide from an antiseptic to an oxygen-producing antihypoxant offers hope for the development of new drugs.
Methods: This manuscript is a meta-analysis performed according to PRISMA guidelines.
Itaconic acid inhibits nontuberculous mycobacterial growth in pH dependent manner while 4-octyl-itaconic acid enhances THP-1 clearance of nontuberculous mycobacteria in vitro.
PLoS One
May 2024
Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, United States of America.
Increasingly prevalent, nontuberculous mycobacteria (NTM) infections affect approximately 20% of people with cystic fibrosis (CF). Previous studies of CF sputum identified lower levels of the host metabolite itaconate in those infected with NTM. Itaconate can inhibit the growth of M.
View Article and Find Full Text PDFCell-free supernatants from Lactobacillus strains exert antibacterial, antibiofilm, and antivirulence activity against Pseudomonas aeruginosa from cystic fibrosis patients.
Microbes Infect
May 2024
Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via S. Zeno 37, 56123 Pisa, Italy. Electronic address:
Chronic lung infections caused by Pseudomonas aeruginosa play a significant role in the mortality and morbidity of cystic fibrosis (CF) patients. The widespread bacterial resistance to conventional antimicrobials demands identifying new strategies to complement or replace current antibiotic therapies. In this study, we evaluated the antibacterial, antibiofilm, and antivirulence properties of cell-free supernatants (CFS) from several Lactobacillus probiotic strains against P.
View Article and Find Full Text PDFSpecific Ventilation in Severe Asthma Evaluated with Noncontrast Tidal Breathing H MRI.
Radiol Cardiothorac Imaging
December 2023
From the Department of Radiation Oncology, Division of Physics, University of California San Francisco, San Francisco, Calif (D.P.I.C.); Division of Respirology, Department of Medicine (A.D.G., P.N., S.S.), Imaging Research Centre (N.B.K., S.S.), and Firestone Institute for Respiratory Health (M.K., P.N., S.S.), St Joseph's Healthcare Hamilton, McMaster University, 50 Charlton Ave E, Hamilton, ON, Canada L8N 4A6; and Lakeshore General Hospital, Montreal Chest Institute, Meakins-Christie Laboratories, and Oscillometry Unit of the Centre for Innovative Medicine, McGill University Health Centre and Research Institute, and McGill University, Montreal, Canada (R.J.D.).
Purpose To determine if proton (H) MRI-derived specific ventilation is responsive to bronchodilator (BD) therapy and associated with clinical biomarkers of type 2 airway inflammation and airways dysfunction in severe asthma. Materials and Methods In this prospective study, 27 participants with severe asthma (mean age, 52 years ± 9 [SD]; 17 female, 10 male) and seven healthy controls (mean age, 47 years ± 16; five female, two male), recruited between 2018 and 2021, underwent same-day spirometry, respiratory oscillometry, and tidal breathing H MRI. Participants with severe asthma underwent all assessments before and after BD therapy, and type 2 airway inflammatory biomarkers were determined (blood eosinophil count, sputum eosinophil percentage, sputum eosinophil-free granules, and fraction of exhaled nitric oxide) to generate a cumulative type 2 biomarker score.
View Article and Find Full Text PDFAcidic pH modulates antimicrobial susceptibility in the cystic fibrosis nutritional environment.
Microbiol Spectr
December 2023
Department of Microbiology and Immunology, Life Sciences Institute, The University of British Columbia, Vancouver, British Columbia, Canada.
causes severe infections in cystic fibrosis (CF) patients. CF patients are prone to reoccurring infections due to the accumulation of mucus in their lungs, where bacteria can adhere and grow. Some of the antibiotics that inhibit in the laboratory are not effective for CF patients.
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