AI Article Synopsis
- Positively charged gold nanoparticles decreased the survival of yeast cells, but did not affect their growth at concentrations between 10 to 100 μg/ml.
- A genome-wide screen identified 17 yeast mutants that showed resistance to gold nanoparticles.
- Analysis revealed a strong correlation with respiration-deficient mutants that were missing genes linked to mitochondrial function.
Article Abstract
Positively charged gold nanoparticles (0.8-nm core diameter) reduced yeast survival, but not growth, at a concentration of 10 to 100 μg/ml. Among 17 resistant deletion mutants isolated in a genome-wide screen, highly significant enrichment was observed for respiration-deficient mutants lacking genes encoding proteins associated with the mitochondrion.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3553748 | PMC |
| http://dx.doi.org/10.1128/AEM.01737-12 | DOI Listing |
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